When mantle cell lymphoma progresses after the first line of treatments, what are the next steps?

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JiaRuanMDPhD (Physician - Oncology - Hematology/Oncology (Verified) ) - 08 / 04 / 2012

As we discussed earlier, MCL tends to run a relapsing course. Managing patients with recurrent or progressive disease after first line therapy is a major component of practice for specialists who care for lymphoma patients. There are many options, both chemotherapy-based, and biologics, that are available for patients whose lymphomas progress after the first line of treatment. The general principle of chemotherapy-based salvage therapy is to apply new combination that the tumors may still be sensitive to. The list of notable biologic options includes bendamustine, bortezomib and lenalidomide, among others. Again, I would highly recommend that patients participate in well-designed clinical trials. One sample of a promising targeted therapy for MCL is a compound called BTK Inhibitor PCI-32765 which is in phase II clinical trials. There are many such examples available in major lymphoma research centers.
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