What parts of the body does metastatic inflammatory breast cancer typically spread?

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BethOvermoyerMD (Physician - Oncology (Verified) ) - 08 / 11 / 2013

IBC, similar to non-IBC, can metastasize to every part of the body, with more common sites depending upon the biologic markers of the cancer. For example, TN IBC, like TNBC in general, has a greater tendency to metastasize to lungs and liver, compared with ER+ disease, which has a greater probability of metastasizing to the bones. In this way, IBC acts similarly to non-IBC, meaning sites of metastasis are dependent upon the molecular biology of the disease. However, IBC does have a propensity to metastasize to the brain and to local organs through lymphatic dissemination. Pleural effusions are more common, as are involvement with distant lymph nodes, such as hilar and mediastinal lymph nodes, as well as the contralateral axillary lymph node groups. IBC also more commonly metastasizes to the other breast through extension of lymphatic involvement in the skin. These are not frequent occurrences, but occur more frequently with IBC than with non-IBC.

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