Join Now
Sign In
What is the significance of the Philadelphia chromosome to chronic myeloid leukemia (CML)? Does it cause leukemia?
Topic Tags:
Topic Tags:
Diseases:
Diseases:
1
Expert Answers
CharlesSchifferMD (Physician - Hematology (Verified) ) - 08 / 31 / 2012
The Philadelphia chromosome, discovered in 1969 in the city of the same name, is found in all patients with CML. It appears under the microscope as a loss of genetic material on chromosome 22, but actually is a consequence of a balanced exchange of DNA between chromosomes 9 and 22 which produces an abnormal gene which in turn produces an abnormal protein called bcr/abl. The bcr/abl protein signals cell growth which is not inhibited by normal mechanisms by which the body regulates the numbers of circulating cells. It is the abnormal bcr/abl which is responsible for the signs and symptoms experienced by patients with CML. With rare exceptions, the cause of the development of the mutation is not known.
Similar Questions
Note: All content on this site is informational and not a substitute for professional medical advice.
Always seek the advice of your physician or other qualified health provider with questions regarding your health.
Note: Usernames have been made anonymous and profile images are not shown to protect the privacy of our members.
Thank you for flagging this content. We will look into it right away.
Add Answer
1) Question:
2) Background Info (optional): What context or background information is relevant to this request?
Notes:
The more clear and thorough your request, the more likely you will receive support.
Many of our members are learning from this information or english might not be their first language. Please use standard english and spell out all words. For example, use 'you' instead of 'u'.
The more clear and thorough your request, the more likely you will receive support.
Many of our members are learning from this information or english might not be their first language. Please use standard english and spell out all words. For example, use 'you' instead of 'u'.
Newsletters
Share Conversation
To tell people about this conversation, type their email addresses here (separated by commas):
From:
Add a personal note here:
CLL (Chronic Lymphocytic Leukemia) Updates
Sign up for our
CLL (Chronic Lymphocytic Leukemia)
updates for the latest news, best answers and featured experts.
Ads keep TalkAboutHealth freeadvertisement
Similar Questions
Updates
Sign up for email updates of the latest news, best answers, and featured experts.
Benefits
Custom health, wellness, & medical offers from our partners including clinical trials, market research opportunities & new programs.
SHARE Support
1) Call SHARE at: 866-891-2392
to speak directly to a trained breast cancer survivor for support and guidance.
2) Direct message the trained peer supporter you select.
3) E-mail us at support@talkabouthealth.com, and we will find the right match for you.
More info
to speak directly to a trained breast cancer survivor for support and guidance.
2) Direct message the trained peer supporter you select.
3) E-mail us at support@talkabouthealth.com, and we will find the right match for you.
More info
3 Quick Ways You Can Help
1) Spread the word! Tell people you think might want some support. Tell medical professionals, health providers, and organizations.
2) Like us on Facebook and follow us on Twitter!
3) Volunteer - email us at volunteer@talkabouthealth.com for more information.
More Ways To Help!
2) Like us on Facebook and follow us on Twitter!
3) Volunteer - email us at volunteer@talkabouthealth.com for more information.
More Ways To Help!
View All Newsletters
