What is the current status of targeted therapies for AML (acute myeloid leukemia)?

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JorgeCortesMD (Physician - Oncology - Hematology/Oncology (Verified) ) - 01 / 04 / 2013

There are multiple targets that are being pursued in AML for therapy and multiple targeted drugs being investigated. Perhaps the most advanced are the FLT3 inhibitors. One currently available is sorafenib. Although it is not approved for the treatment of AML, it is a potent inhibitor of FLT3 and several studies have suggested that it may have a role in the treatment of AML, although its precise role and place in the treatment of AML is still being defined. Many other FLT3 inhibitors are being investigated including midostauin, quizartinib, crenolanib, and others. Monoclonal antibodies have also been used and there was a drug called gentuzumab ozogamycin that was available for some time. This was a monoclonal antibody against CD33 attached to a toxin, calicheamycin. It had some activity in the salvage setting given by itself, and recent studies have suggested that, when added to chemotherapy, may improve the outcome of some patients with AML. There are many other targeted drugs being investigated but they are much earlier in their development, including inhibitors of MEK, c-met, etc.
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