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What biomarkers and measurements do you follow when treating glioblastoma?
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MarkGilbertMD (Physician - Neuro-Oncology (Verified) ) - 07 / 23 / 2012
Tumor measurements during active treatment, typically using magnetic resonance imaging (MRI) are a critical component of successful patient care. On rare occasions when patients are unable to undergo MRI, computed tomography (CT) is used. Brain tumors are very complex and this is accentuated by changes on MRI that are caused by treatment. For example, recent studies have shown that soon after completion of concurrent radiation and temozolomide for glioblastoma, nearly half of the patients have imaging studies that show an increase in the size of the abnormality. However, many of these patients do not have tumor progression, rather changes that are directly caused by the treatment. These changes, called “pseudoprogression” are indistinguishable from tumor progression. Making the distinction is typically done by continuing treatment and providing frequent tumor imaging. Pseudoprogression will improve over time, whereas true tumor progression will continue to worsen.
To date, there are no blood markers that have been shown to be useful in monitoring tumor activity as exists for other cancers such as the PSA for prostate cancer.
To date, there are no blood markers that have been shown to be useful in monitoring tumor activity as exists for other cancers such as the PSA for prostate cancer.
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