What are the advantages and disadvantages of having non-ablative conditioning rather than ablative conditioning?

Expert Answers

CarolynMulroneyMD (Physician - Hematology (Verified) ) - 09 / 12 / 2013

The advantage of an ablative conditioning regimen is that there is more anti tumor or anti leukemia effect than a reduced intensity or a nonmyeloablative regimen would have. Relapse rates tend to be lower after ablative regimens. The disadvantage of ablative conditioning id that there is a higher rate of treatment toxicity such as VOD/SOS. In some diseases the added benefit of ablative treatment does not outweigh the toxicity. Acute Graft versus host disease can also be more severe with ablative regimens.
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