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Is there any circumstance when the letrozole (Femara) dose will be changed or decreased?

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Topics (Tags):

Hormone Receptor Positive (HR+) Breast Cancer Treatments Letrozole (Femara) Breast Cancer Aromatase Inhibitors Medications Breast Cancer Medications Adjuvant Therapy Post-menopausal Non-steroidal Aromatase Inhibitors

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Answers (1)

JKJones (Pharmacist (Verified) ) - 09 / 03 / 2011

There is no dosage adjustment of letrozole for patients with normal kidney and liver function. The physician will monitor for kidney and liver function using kidney and liver function tests and change medications if needed.

- With mild to moderate impairment of the liver, the dose of letrozole will not be changed.
- For post menopausal women taking Letrozole with liver problems (cirrhosis and severe hepatic impairment), as determined by liver function tests, the dose recommended for this patient population is 2.5mg every other day.
- There is no change in dosage requirements for patients with a creatinine clearance of the kidneys greater than or equal to 10ml/min.

For more information on this subject, see the following links:
http://www.rxlist.com/femara-drug.htm
http://www.drugs.com/dosage/letrozole.html

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Latest Activity: 09 / 04 / 2011
Views: 227
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