Inhibitors

Yes, I can except that I cannot give a specific. Angiogenesis is triggered by three main receptor VEGFR 1, VEGFR 2, and VEGFR 3. You can inhibit one of these receptor or two receptors, or three receptors. Further, some people approach inhibit the ligand (stimulant of receptor). Stopping the ligand is the approach of Bevacizumab (Avastin).

So the main question is wether the ligands or the receptors important in creating new blood vessels that can nurture the cancer more. The answer is that we do not have a clear cut answer. Therefore, the thought is why not inhibit all three receptors. Because we speculate that all three receptors promote inflammatory breast cancer to be aggressive, we feel that is worth testing a drug that inhibit all three receptors.
Yes, I can except that I cannot give a specific. Angiogenesis is triggered by three main receptor VEGFR 1, VEGFR 2, and VEGFR 3. You can inhibit one of these receptor or two receptors, or three receptors. Further, some people approach inhibit the ligand (stimulant of receptor). Stopping the ligand is the approach of Bevacizumab (Avastin).

So the main question is wether the ligands or the receptors important in creating new blood vessels that can nurture the cancer more. The answer is that we do not have a clear cut answer. Therefore, the thought is why not inhibit all three receptors. Because we speculate that all three receptors promote inflammatory breast cancer to be aggressive, we feel that is worth testing a drug that inhibit all three receptors.