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I'm a 3rd primary, post mastect., Stage I, ER/PR +, BRCA 1/2 negative, HER2-, OncotypeDX score 22. My oncologist says no to chemo. What is your take on this?

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He is sending me to UCLA for a 2nd opinion as I fall in that 'middle gray area' on the Onco. Dx Test. I will also be taking hormone blockers starting within the month.

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Topics (Tags):

Chemotherapy Decision Patient Decisions Breast Cancer Chemotherapy

Topics:

Chemotherapy Decision X Patient Decisions X Breast Cancer X Chemotherapy X

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Diseases:

Breast Cancer

Diseases:

Breast Cancer

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Answer Summary

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Answers (2)

ShelbyTerstriepMD (Physician - Oncology - Hematology/Oncology (Verified) ) - 02 / 17 / 2012

I agree it is a grey zone. I would recommending proceeding with the second opinion. At this point in the intermediate risk on oncotype it often comes down to discussing the risks of chemo versus possible benefit and then the patient saying they are willing to take the risks even though the benefit may be small.

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kwagnermd (Physician - Surgery - General (Verified) ) - 02 / 15 / 2012

More info would be helpful such as this is your third time to have breast cancer or were there 3 primaries in the same breast? Are you pre or post menopausal? If previously treated for breast cancer, did you get any chemo? What was the size and grade of the tumor?

In general, an intermediate score [on the low side] with a low grade, low risk lesion in a postmenopausal woman would lead to no chemo recommendation, but with pathology in hand, the doctors at UCLA should be able to give you a good recommendation.

There are clinical trials regarding intermediate Oncotype DX scores out there, have you looked at them?

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Latest Activity: 02 / 17 / 2012
Views: 102
Followed By: 3 members