I do not tolerate Tamoxifen or aromatase inhibitors. Is anyone aware of alternate estrogen inhibitors or other options?

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member1665 (Survivor (2 - 5 years)) - 01 / 11 / 2012

I didn't tolerate Tamoxifen either and I am premenopausal. My doctor suggested ovarian supression with Lupron injections or having the ovaries removed. I have not done either because my gyn. suggests this can cause problems with bone and heart health in young women who still need some levels of estrogen. My oncologist told me that in my particular case, being heavily her2+++, that Tamoxifen offered me about only a 3% reduction in recurrence and that the her2+ was my larger risk factor. I have decided to not look back and stop obsessing about it all. I have had chemo and mastectomy.

member1751 (Caregiver) - 01 / 11 / 2012

My partner is also premenopausal, and has refused taking Tamoxifen, despite being ER+. Instead, she has opted for use of bio-identical hormones. 2-methoxyestradiol has been demonstrated to have the SERM like qualities of Tamoxifen, however, with no side effects. In addition, it has specific anti-cancer properties. We referencehttp://lib.bioinfo.pl/pmid:15156405 as one study among many. Good luck with your choice!
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