Hyperplasia

Ductal hyperplasia refers to a proliferative condition in which there is increased cellularity of the lining epithelium. It is classified into usual (regular or ordinary) hyperplasia and atypical hyperplasia. The diagnosis is made on breast biopsy.

Atypical lobular hyperplasia is characterized by abnormal cells within one or more of the breast lobules.

Both atypical ductal and atypical lobular hyperplasia are associated with an increased risk of breast cancer. The Gail model incorporates the presence of atypia into risk assessment http://www.cancer.gov/bcrisktool/

If the 5 year risk of breast cancer calculated by this model is 1.67% or more, then chemporeventive drugs such as tamoxifen, raloxifene or exemestane may be offered to reduce risk.

Patients with atypia found on a core needle biopsy should undergo excisional biopsy of the surrounding tissue to exclude a nearby cancer. Ductal hyperplasia refers to a proliferative condition in which there is increased cellularity of the lining epithelium. It is classified into usual (regular or ordinary) hyperplasia and atypical hyperplasia. The diagnosis is made on breast biopsy.

Atypical lobular hyperplasia is characterized by abnormal cells within one or more of the breast lobules.

Both atypical ductal and atypical lobular hyperplasia are associated with an increased risk of breast cancer. The Gail model incorporates the presence of atypia into risk assessment http://www.cancer.gov/bcrisktool/

If the 5 year risk of breast cancer calculated by this model is 1.67% or more, then chemporeventive drugs such as tamoxifen, raloxifene or exemestane may be offered to reduce risk.

Patients with atypia found on a core needle biopsy should undergo excisional biopsy of the surrounding tissue to exclude a nearby cancer.