How do aromatase inhibitors work?
Diseases:
1
Expert AnswersJKJones (Pharmacist (Verified) ) - 07 / 18 / 2011
As the name implies, the action of Aromatase Inhibitors is to inhibit the production of estrogens by stopping the conversion of androgen into estrogen. Aromatase inhibitors operate by blocking the aromatase enzyme that converts androgen to estrogen. Post-menopausal women get estrogen from the conversion of androgen into estrogen in the tissues of the body. In contrast pre-menopausal women get estrogen from the ovaries. By inhibiting the production of the estrogen, the estrogen receptor [ER]-positive and/or progesterone receptor [PR]-positive tumors in the breast cannot grow.
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