For Stage 1 breast cancer, what factors determine if chemotherapy is recommended?

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EllenChuangMD (Physician - Oncology - Hematology/Oncology (Verified) ) - 08 / 03 / 2012

Chemotherapy is often recommended for stage 1 cancers if the cancer is ER negative or Her2/neu positive. In the absence of adverse features such as high nuclear grade or lymphovascular invasion, cancers that are ER positive and Her2/neu negative may be treated with hormonal therapy alone, and may not need chemotherapy. The Oncotype 21 gene assay is a molecular test that is often performed for stage 1 ER positive Her2/neu negative cancers. The test has been a valuable tool to help determine whether the addition of chemotherapy to hormonal therapy would be of benefit for a particular individual.
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