For inflammatory breast cancer, does it matter if it is ER+ or Her2+?

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BethOvermoyerMD (Physician - Oncology (Verified) ) - 08 / 11 / 2013

IBC is more commonly found to be HER2+ or triple negative (TN) compared with non-IBC. The prognosis for IBC that is ER+ is more favorable than if ER negative, most likely because the cancer can be treated with endocrine therapy (tamoxifen, aromatase inhibitors) following the completion of chemotherapy. HER2+ IBC also has a more favorable outcome, because medication specifically directed toward the treatment of HER2+ disease (trastuzumab, pertuzumab) has been shown to be very successful. Within IBC, TN disease remains problematic because of the limited therapies available, namely only chemotherapy.

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