Estrogen Inhibitors

My partner is also premenopausal, and has refused taking Tamoxifen, despite being ER+. Instead, she has opted for use of bio-identical hormones. 2-methoxyestradiol has been demonstrated to have the SERM like qualities of Tamoxifen, however, with no side effects. In addition, it has specific anti-cancer properties. We reference http://lib.bioinfo.pl/pmid:15156405 as one study among many. Good luck with your choice!

Seek out a naturopathic doctor within your area and inquire about Helixor or Iscador. They are both injectables which has been used with great clinical success in patients with cancer.

You could also inquire about a few herbals/neutraceuticals which can strengthen your body & decrease the side effects of the chemotherapeutics.

In terms of diet, it is important to support optimal hormone function - and yes, this can come down to bowel movements. If you do not have daily regular bowel movements, hormones that your body has metabolized sits in your colon & can be released back into your system. To avoid this, I encourage the use of professional grade probiotics, 2 TBL of freshly ground flax seeds & 1 TBL of chia seeds daily, in addition to keeping well hydrated (water, sugar-free organic coconut water instead of pop/juice) throughout the day.

Additional naturopathic alternatives should be discussed with you ND as they can tailor a protocol specific to your needs.

If you have forgotten to take your letrozole dose, take it as soon as possible. But if it is close to the time for the next dose just take the next dose and continue your usual dosing times. In order to remember to take your letrozole, consider taking it at the same time everyday. Letrozole can be taken with or without food.

Do not take more than one dose of letrozole a day.

All three aromatase inhibitors are generic. There are three aromatase inhibitors:

Anastrozole (Arimidex) is a 1mg oral tablet taken once daily.
Letrozole (Femara) is a 2.5mg once daily oral tablet which may be taken without regards to meals.
Exemestane (Aromasin) is a 25mg. once daily oral tablet which should be taken after a meal.

Letrozole is categorized pharmacologically as an Antineoplastic Agent and as an Aromatase Inhibitor. The action of Aromatase Inhibitors is to inhibit the production of estrogens by stopping the conversion of androgen into estrogen.

- Aromatase Inhibitors operate by blocking the aromatase enzyme from converting androgen to estrogen in women who have gone through menopause.
- Post-menopausal women get estrogen from the conversion of androgen into estrogen in the tissues of the body.
- In contrast women who have not gone through menopause receive their estrogen from the ovaries.
- By inhibiting the production of estrogen, the estrogen receptor [ER]-positive and/or progesterone receptor [PR]-positive tumor breast cancer cells cannot grow.

If you have forgotten to take your anastrozole dose, try to take it as soon as possible. But if it is close to the time for the next dose just take the next dose and continue your usual dosing times. In order to remember to take your anastrozole, consider taking it at the same time everyday. Anastrozole can be taken with or without food.

You should not double your dose if a dose has been missed.