Daunorubicin (Cerubidine/Daunoxome)

Causes of hyperpigmentation, which is a more than normal pigmentation of the body, usually of the skin include:
- changes in hormones, pregnancy, or Addison's disease
- sun damage or sun exposure
- injuries
- a particular skin type
- acne
- medications, such as chemotherapy drugs.

The chemotherapy drugs are that may cause hyperpigmentation are Fluorouracil (5-FU), Cytoxan, Alkeran, Myleran, Bleomycin (Blenoxane), Adriamycin, Daunorubicin, and the topical treatment BCNU.

Generally, hyperpigmentation caused by chemotherapy is short-lived. The darkening of the skin usually slowly fades when the offending chemotherapy medication is discontinued.