Theresa Guise, MD
- Oncology - Hematology/Oncology
Theresa A. Guise, M.D., professor of medicine and Jerry W. and Peg S. Throgmartin professor of oncology in the Division of Endocrinology at the Indiana University School of Medicine.
Dr. Guise’s principal laboratory interests encompass skeletal complications of malignancy: tumor metastasis to bone and the effect of cancer treatment on skeletal health. Specifically, she studies the molecular mechanisms by which tumor cells interact with bone cells to cause either bone destruction (osteolytic metastases) or new bone formation (osteoblastic metastases) using mouse models. The effect of cancer treatments, such as androgen deprivation for prostate cancer and aromatase inhibitors for breast cancer, on bone mass as well as the development and progression of bone metastasis is under investigation. In these areas, she is currently involved as principal investigator in several grant-funded research projects from the NIH and the Department of Defense.
Dr. Guise’s clinical interests encompass diseases of calcium and bone metabolism, and she is Principal Investigator on several clinical trials. She was elected to the American Society for Clinical Investigation in 2004 and is a permanent member of the NIH study section of Skeletal Biology, Structure and Regeneration.
Oncology - Hematology/Oncology
University of Pittsburgh School of Medicine
University Pittsburgh Health Center
University Texas Health Science Center
Areas of expertise:
Effects of Cancer and Cancer Treatment on Bone, Bone Metastases, Osteoporosis. Pagets Disease
Our current research program encompasses skeletal complications of cancer and cancer therapy. Funded programs include those on TGFbeta signaling and bone metastases, role of hypoxia in bone metastases, adrenomedullin in bone metastases, endothelins in pathological and normal bone remodeling.
Indiana University Melvin and Bren Simon Cancer Center
980 W. Walnut Street R3 C132
Practice phone number: