JKJones's Answers (187)
The most common side effects of crizotinib (Xalkori) are:
- Gastrointestinal side effects which include nausea, vomiting, decreased appetite, diarrhea, constipation
- Swelling of hands and feets (edema)

Less common side effects include:
- Mild dizziness
- Fatigue
- Insomnia
- Mild rash
- Numbness or tingling
- Cold symptoms
- Arthralgia and back pain


Side effects that are not as common but may present problems are:
- Pneumonitis
- Hepatic liver abnormalities (elevated ALT (alanine aminotransferase) and AST (aspartate aminotransferase) levels
- QT Prolongation which is an irregular heart rhythm

Crizotinib (Xalkori) side effects vary greatly from patient to patient depending on different issues including patient history, existing conditions, other prescribed medications the patient is taking, and stage of disease. Some people experience minimal side effects, while others may experience severe side effects.

If the side effects from Xalkori are severe, you may speak to your physician about medications to treat the side effects. It is important to notify your physician if and when you develop any side effects and to listen to your body and call your healthcare provider if something seems amiss.

Websites that may provide more information include:

http://www.drugs.com/xalkori.html
http://www.pfizerpro.com/hcp/xalkori_home??source=google&HBX_PK=s_+xalkori&HBX_OU=50&o=69985681|245244793|0&skwid=43700003139871797
http://www.rxlist.com/xalkori-drug/side-effects-interactions.htm
Question by: member4968 (Family member) in topic(s) Drugs, Crizotinib (Xalkori), Lung Cancer, Medications, Side Effects
Both you and your physician will be monitoring the potential risks of letrozole.

The risks that may cause the most concern are:
- Decreases in bone mineral density (BMD).
- Increases in cholesterol.

The patient should be aware and notify the physician of any changes in how they feel, particularly paying attention to bone pain and liver pain (upper right quadrant).

The way to monitor these risks are through the following:
- bone density test
- complete blood cell counts (CBC)
- thyroid function tests
- monitoring serum electrolytes
- monitoring cholesterol and liver function tests, kidney function, and blood pressure.

There will also be the physical assessment of the patient. This will include blood pressure readings, pain assessment, gastrointestinal upsets, and hot flashes.

When initiating letrozole treatment, patients may experience dizziness and fatigue. Until your body adjusts be cautious before performing work that requires mental alertness, such as driving.

For more information, see the follwing links:

http://www.rxlist.com/femara-drug.htm
http://www.webmd.com/drugs/drug-4363-Femara+Oral.aspx?drugid=4363&drugname=Femara+Oral
Both you and your physician will be monitoring the potential risks of anastrozole.

The risks that may cause the most concern are:
- Decreases in bone mineral density (BMD). (Potential increase in bone loss.)
- May cause higher cholesterol levels or liver disease.
- Patient's with heart disease may have more of a chance to experience an ischemic cardiovascular event. (An ischemic cardiovascular event is reduced blood supply to the muscles of the heart).

The patient should be aware and notify the physician of any changes in how they feel, particularly paying attention to bone pain, chest pain, or liver pain (upper right quadrant).

The way to monitor these risks are through the following:
- bone density test
- complete blood cell counts (CBC)
- monitoring cholesterol and liver function tests
- thyroid function tests
- monitoring serum electrolytes
- kidney function, and blood pressure.


There will also be the physical assessment of the patient and monitoring for the postmenopausal women taking anastrozole. This will include blood pressure readings, pain assessment, gastrointestinal upsets, and hot flashes.

When initiating anastrozole treatment patients may experience dizziness and fatigue. Until your body adjusts be cautious before performing work that requires mental alertness, such as driving.

For more information, see the following link:
http://www.rxlist.com/arimidex-drug.htm
Anastrozole is indicated for:
- Treatment of hormone receptor-positive early and metastatic breast cancer in post-menopausal women. It may be used alone or after surgery or radiation. (Early breast cancer is cancer that has not spread outside the breast to other parts of the body.)
- Treatment of hormone receptor-positive breast cancer that has progressed after receiving tamoxifen treatment for post-menopausal women.
- Post-menopausal women where the ER-positive or hormone receptor unknown breast cancer has spread in the breast or to other parts of the body.

For more information, see the following link:
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000982/
There is no dosage adjustment for patients taking anastrozole with normal liver function. The physician will monitor the patient's liver function and change medications if needed.
- For elderly post-menopausal women, there are no recommendations to change the dose.
- For patients with mild to moderate liver disease, as determined by liver function tests, there are no recommendations to change the dose.
- In patients with severe liver disease there have been no studies to conclude if the dose should be changed. The physician will decide whether to change medications.

For more information, see the following links:
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000982/
http://www.drugs.com/pro/arimidex.html
http://www.rxlist.com/arimidex-drug.htm
There is no dosage adjustment of letrozole for patients with normal kidney and liver function. The physician will monitor for kidney and liver function using kidney and liver function tests and change medications if needed.

- With mild to moderate impairment of the liver, the dose of letrozole will not be changed.
- For post menopausal women taking Letrozole with liver problems (cirrhosis and severe hepatic impairment), as determined by liver function tests, the dose recommended for this patient population is 2.5mg every other day.
- There is no change in dosage requirements for patients with a creatinine clearance of the kidneys greater than or equal to 10ml/min.

For more information on this subject, see the following links:
http://www.rxlist.com/femara-drug.htm
http://www.drugs.com/dosage/letrozole.html
Letrozole (Femara) may be employed for breast cancer in these circumstances:
- Early adjuvant treatment for hormone receptor positive (HR+) breast cancer in post-menopausal women. It is unknown how long letrozole should be taken, but the duration of the clinical trial was 5 years. Adjuvant treatment is the administration of letrozole after surgery, radiation, and/or chemotherapy.
- Extended adjuvant treatment for hormone receptor positive (HR+) breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen treatment. The ideal length of treatment is not known, as the international study of 5,187 postmenopausal women discovered that when letrozole was taken after completing five years of tamoxifen therapy, there was a decrease in breast cancer recurrences. Treatment may be discontinued if there is a relapse.
- As first or second-line treatment of breast cancer that has advanced in menopausal women after anti-estrogen treatment. Administration may be continued until the breast cancer tumor worsens or metastasizes.
- Locally advanced or metastasized breast cancer with hormone receptor positive or unknown hormone origin.

Here are a couple of other sites to visit for more information.
http://www.ncbi.nlm.nih.gov/pubmed/15161328
http://www.cancer.gov/cancertopics/druginfo/letrozole
As a woman, some of the risk factors you can control to decrease your chance of breast cancer are:
- Controlling your weight
- A nutritious well-balanced diet with lots of fruits, vegetables, grains, and lots of fluid.
- Sticking to a regular exercise routine that includes employing weights, stretching, and aerobic exercise.
- Limiting the amount of alcohol that is consumed.
- Limiting estrogen and oral contraceptives.
- Trying to reduce anxiety and stress in everyday life.
Question by: member4187 (High Risk Individual) in topic(s) Reduce Breast Cancer Risk, Breast Cancer, Breast Cancer Risk
Anastrozole treats breast cancer by inhibiting the production of estrogen in tissues of the body of post-menopausal women.
- By inhibiting the production of estrogen, the estrogen receptor [ER]-positive and/or progesterone receptor [PR]-positive cancer cells cannot grow.
- Anastrozole operates by blocking the aromatase enzyme that converts androgen to estrogen in the tissues of women who have gone through menopause.
- Postmenopausal women get estrogen from the conversion of androgen into estrogen in the tissues of the body.
- In women who have not gone through menopause, they receive their estrogen from the ovaries.
- Anastrozole is categorized pharmacologically as an antineoplastic agent and as a nonsteroidal aromatase inhibitor and is indicated for postmenopausal women.
Letrozole (Femara) is an antineoplastic agent. Antineoplastic agents are anticancer medications. Letrozole is also categorized as a nonsteroidal aromatase inhibitor. Aromatase inhibitors do not allow the aromatase enzyme to convert androgen into estrogen in the tissues. By blocking estrogen production in the tissues of the body, the estrogen receptor [ER]-positive and/or progesterone receptor [PR]-positive) breast cancer cells cannot grow.
When initiating treatment with Letrozole, here are some topics to be aware of and inform your physician:
- What allergies you have and if you've ever experienced an allergy to Letrozole.
- Your medical history including if you have any issues with cholesterol, liver disease, bone complications, history of stroke or blood clots, heart disease, high blood pressure, or kidney issues.
- Any other medications you are taking and this includes prescription medications, all over-the-counter products you are taking, vitamins, and herbal remedies as they might contain estrogenic components or promote estrogen activity.
- Any other medications that you are taking that contain estrogen such as hormone replacement drugs or hormonal contraceptives which includes all birth control products such as contraceptive pills, patches, rings, or injections.
- If you are taking tamoxifen or raloxifene.
- Women who are perimenopausal or recently menopausal should employ contraception methods until postmenopausal status is achieved. Letrozole is harmful to the fetus.
- If you are pregnant or breast feeding.
Letrozole is a 2.5mg tablet to be taken once daily. It may be taken with or without food, preferably at the same time every day. It may be taken without regard to meals. Calcium and vitamin D supplementation are recommended.
As the name implies, the action of Aromatase Inhibitors is to inhibit the production of estrogens by stopping the conversion of androgen into estrogen. Aromatase inhibitors operate by blocking the aromatase enzyme that converts androgen to estrogen. Post-menopausal women get estrogen from the conversion of androgen into estrogen in the tissues of the body. In contrast pre-menopausal women get estrogen from the ovaries. By inhibiting the production of the estrogen, the estrogen receptor [ER]-positive and/or progesterone receptor [PR]-positive tumors in the breast cannot grow.
If you have forgotten to take your letrozole dose, take it as soon as possible. But if it is close to the time for the next dose just take the next dose and continue your usual dosing times. In order to remember to take your letrozole, consider taking it at the same time everyday. Letrozole can be taken with or without food.

Do not take more than one dose of letrozole a day.
All three aromatase inhibitors are generic. There are three aromatase inhibitors:

Anastrozole (Arimidex) is a 1mg oral tablet taken once daily.
Letrozole (Femara) is a 2.5mg once daily oral tablet which may be taken without regards to meals.
Exemestane (Aromasin) is a 25mg. once daily oral tablet which should be taken after a meal.
Letrozole is categorized pharmacologically as an Antineoplastic Agent and as an Aromatase Inhibitor. The action of Aromatase Inhibitors is to inhibit the production of estrogens by stopping the conversion of androgen into estrogen.

- Aromatase Inhibitors operate by blocking the aromatase enzyme from converting androgen to estrogen in women who have gone through menopause.
- Post-menopausal women get estrogen from the conversion of androgen into estrogen in the tissues of the body.
- In contrast women who have not gone through menopause receive their estrogen from the ovaries.
- By inhibiting the production of estrogen, the estrogen receptor [ER]-positive and/or progesterone receptor [PR]-positive tumor breast cancer cells cannot grow.
A side effect of Tamoxifen may include neuromuscular & skeletal pain and that includes bone pain also called arthralgia.
This adverse effect has been reported in approximately 6% of patients according to Lexicomp's Drug Information Handbook for Oncology.

Two websites that may interest you regarding side effects of Tamoxifen are:
-http://www.rxlist.com/nolvadex-drug.htm
-http://www.mayoclinic.com/health/drug-information/DR601293/DSECTION=side-effects
A respiratory side effect of Tamoxifen can include coughing which has been reported in approximately 4% of the patients according Lexicomp's Drug Information Handbook for Oncology.

- It is important to consult with your health care provider about the coughing as it may be a sign of infection as Tamoxifen may alter your body's ability to ward off infections.
- It is also important to take precautions around people with colds or infections.

Other less common side effects are listed on these two websites:
-http://www.rxlist.com/nolvadex-drug.htm
-http://www.mayoclinic.com/health/drug-information/DR601293/DSECTION=side-effects
A respiratory side effect of Tamoxifen can include coughing which has been reported in approximately 4% of the patients according Lexicomp's Drug Information Handbook for Oncology.

- It is important to consult with your health care provider about the coughing as it may be a sign of infection as Tamoxifen may alter your body's ability to ward off infections.
- It is also important to take precautions around people with colds or infections.

Other less common side effects are listed on these two websites:
-http://www.rxlist.com/nolvadex-drug.htm
-http://www.mayoclinic.com/health/drug-information/DR601293/DSECTION=side-effects
Anastrozole is taken by mouth as a 1mg. tablet once daily at the same time everyday.
- Always follow the directions on the prescription label and if you have any questions, consult with your physician and pharmacist.
- Storage of the drug should be in a dry place at room temperature. Avoid storing in the bathroom and exposing the medication to extreme heat or dampness.
- It is important to discard the medication appropriately and if it is outdated, do not take the anastrozole.
- Continue taking anastrozole as long as your physician requests and do not stop this drug without consulting your physician.
Anastrozole (Arimidex) is an anticancer drug. It is a type of nonsteroidal aromatase inhibitor. Anastrozole works by decreasing the estrogen production in the body by inhibiting the enzyme that converts androgens into estrogen. By decreasing the amount of estrogen in the body, tumors that need estrogen to grow are inhibited.
If you have forgotten to take your anastrozole dose, try to take it as soon as possible. But if it is close to the time for the next dose just take the next dose and continue your usual dosing times. In order to remember to take your anastrozole, consider taking it at the same time everyday. Anastrozole can be taken with or without food.

You should not double your dose if a dose has been missed.
Medications to avoid or speak to your physician about are:
-Estrogen products such as hormone replacement medications (oestrogel) or birth control medications because they decrease the efficacy of anastrozole.
-Tamoxifen may interact with anastrozole and decrease the efficacy of anastrozole.
-Thalidomide may interact with anastrozole.
-The following herbals should be avoided because they may decrease the efficacy of anastrozole - black cohosh, don quai, Motherwort, Vitex, hops, licorice, red clover, and thyme.
-Medicines similar to luteinizing hormone releasing hormone
Anastrozole is not advised if:
- Patient is allergic to anastrozole. Please share with your healthcare provider any allergies you have.
- Patient is pregnant or breastfeeding.
- Please share with your healthcare provider if you are taking hormone replacement medications or birth control medications.
- The administration of Tamoxifen and anastrozole (Arimidex) at the same time is not recommended.
- Patient has not gone completely through menopause.
- Please advise healthcare provider with a list of your diseases, such as a history liver or heart disease, circulation issues such as blood clots or strokes, and osteopenia.
Some of the risk factors that are used to determine if someone is at high risk for breast cancer are:
- if a woman had breast cancer in one breast, there is an increased risk of developing cancer in the other breast unrelated to the first cancer.
- direct family history increases the risk of breast cancer, especially if the family history is a first degree relative.
- having two first-degree relatives who had breast cancer further increases risk
- generationally if the cancer in the family was in both breasts
- if a breast biopsy revealed atypical hyperplasia (lobular or ductal)
- if the woman tested positive for BRCA -1 or BRCA-2 positive
- if the woman's relatives tested BRCA positive
- if your ancestry is Eastern and Central European (Ashkenazi) Jewish
- if ovarian cancer has been in the family
- if a male relative has had breast cancer
- if the person experienced chest radiation between the ages of 10-30
Breast cancer is not a result of wearing bras or how your breasts are fondled or touched.

Breast cancer is caused by cancer cells. The theory that bras cause cancer is not supported by evidence.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Wearing Bras, Bras, Breast Cancer, Breast Cancer Causes
"Cysts are not cancers and there is no evidence that cysts become cancers. Cysts are sacs in the breast filled with fluid that feel like a "lump."

Breast cysts are common especially among women between the ages of 40-60. Breast ultrasound identifies cysts. It is extremely important to find out whether what you have is just a cyst or something else.

Breast cysts are categorized as simple cysts or complex cysts. "Simple Cysts" are identified and are generally benign being round or oval with smooth edges. "Complex Cysts" contain debris and aspiration is usually required. Techniques used for aspiration (biopsy) include fine-needle aspiration (also called percutaneous), core-needle biopsy, and surgical biopsy.

The pathologist will check the fluid obtained from the aspiration to determine there are no cancer cells.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Simple Cysts, Lump In Breast, Complex Cysts, Cysts, Lumps
Melasma is discoloration of the skin and is also known as hyperpigmentation.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemotherapy Side Effects, Hyperpigmentation, Melasma, Side Effects, Skin Discoloration
Patients with neutropenia should follow a neutropenic diet. A neutropenic diet limits exposure to bacteria, thereby lessening the chance of food-borne illnesses. The goal of your diet should be to keep your immune system strong to fight infections.

Some suggestions are:
- High protein diet including mature beans.
- High fiber diet.
- Make sure to wash, peal, and wear plastic disposable gloves when preparing fruit, meats, and vegetables. The peal or outer surfaces can contain bacteria and it is important to avoid infections.
- Eating thick-skinned fruits like oranges, bananas, melons is advised.
- Avoid unpasteurized milk, milk products, non pasteurized cheeses, and any yogurt with live and active cultures.
- Always eat well cooked meat. Eat vacuum-packed lunch meats and not freshly sliced meats.
- Avoiding raw foods, such as honey, loose teas, unwashed fresh vegetables and fruits because of the potential of E.coli contamination.
- Lots of fruits and vegetables because they contain cancer fighting properties.

Here are links to more information:
http://www.livestrong.com/article/356481-neutropenic-diet/#ixzz1JFYKweTf
http://www.caring4cancer.com/go/cancer/nutrition/questions/neutropenic-diet-questions.htm
Question by: JKJones (Pharmacist (Verified)) in topic(s) Neutropenia, Neutropenic Diet, Diet
If you are experiencing skin discoloration or hyperpigmentation due to medications, specifically chemotherapy medication treatment, this discoloration usually disappears about 10 to 12 weeks after the completion of treatment. Your old skin cells are replaced with new skin cells.

As with all side effects and their treatment discuss your concerns with your physician.

Here are links to more information on skin discoloration:
http://www.breastcancer.org/treatment/side_effects/skin_discolor.jsp
http://www.chemocare.com/managing/skin_reactions.asp
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemotherapy Side Effects, Hyperpigmentation, Side Effects, Skin Discoloration
Hyperpigmentation is a skin reaction in which patches of skin or the skin overall may become darker in color due to the release of melanin. Melanin is a pigment in skin cells that gives the skin its color. Hyperpigmentation is usually a harmless condition that resolves itself at the end of the treatment.

Hyperpigmentation may be caused by medications or it may be a phototoxic reaction. Some chemotherapy agents can cause blotchy or generalized hyperpigmentation. This darkening of the skin may occur around the joints or under the nails, in the mouth or along the vein used to infuse chemotherapy drug. Sometimes it's limited just to the site of infusion; but sometimes it's more generalized and covers larger areas of the body.

This blotchiness or darkening of the skin often appears 2 to 3 weeks after chemotherapy treatment begins and disappears or goes away as new skin cells are generated and replace the dead cells 10 to 12 weeks after treatment is over. Chemotherapy agents associated with temporary pigmentation are melphalan, busulfan, cyclophosphamide, 5-fluorouacil, adriamycin, daunorubicin, bleomycin, and topical BCNU.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Melasma, Hyperpigmentation, Skin Discoloration
Paclitaxel is a chemotherapeutic agent (chemotherapy drug) used to treat breast cancer. It belongs to a group of anti-cancer medications called taxanes.

Paclitaxel works by inhibiting or stopping cancer cell division. Drugs that inhibit cell division are called mitotic inhibitors. Paclitaxel was found and isolated from the bark of the Pacific Yew tree. It is now produced using plant cell fermentation technology.

It is surmised that cells treated with Paclitaxel have defects in mitotic spindle assembly (framework of cells), chromosome segregation, and cell division.

As a woman, some of the risk factors you can control to decrease your chance of breast cancer are:
- Controlling your weight
- A nutritious well-balanced diet with lots of fruits, vegetables, grains, and lots of fluid.
- Sticking to a regular exercise routine that includes employing weights, stretching, and aerobic exercise.
- Limiting the amount of alcohol that is consumed.
- Limiting estrogen and oral contraceptives.
- Trying to reduce anxiety and stress in everyday life.
Over the counter treatments for hyperpigmentation are:
- Hydroquinone is a bleaching agent that blocks melanin by decreasing the manufacturing of melanin and assisting in the breakdown of melanin in the skin. Weaker concentrations of hydroquinone (2-4%) may be obtained over the counter.
- Alpha hydroxy acids, such as 8 percent glycolic acid, are water soluble acids which work by renewing skin cells and correcting the darkened skin.
- Beta hydroxy acids (such as salicylic acid) are exfoliants which cause flaking off of the skin.
- Kinerase is a C8 peptide containing kinetin which increases cell division, thereby the darker skin cells are eliminated.

Prescription treatments are:
- Higher doses of hydroquinone.
- Topical retinoid (derived from Vitamin A), is called Retin-A. It is an exfoliating agent which speeds up new skin growth, diminishing dark skin pigmentation. Prescription products of stronger concentrations are: Retin-A, Renova, Avita, etc.
- A combination prescription product called Tri-Luma contains both hydroquinone and Retin-A Cream (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%)

Chemical peels which are skin pigmentation treatments may also be considered. The different products are: alpha hydroxy acid peels, beta hydroxy acid peels, Jessner's peel, retinoic acid peel, trichloroacetic acid peels, phenol peels.
The American Cancer Society recommends yearly screening mammograms and MRIs for women with an approximately 20–25% or greater lifetime risk of breast cancer, including women with a strong family history of breast or ovarian cancer. (http://caonline.amcancersoc.org/cgi/content/full/57/2/75)

When you speak to your physician about this, it is important that you understand the benefits, limitations, and harms of different screening strategies and the degree of uncertainty about each. You may also want to speak to your physician about ultrasound as an option.

Since you have such a strong family history of breast cancer, if you haven't already, you may want to consider genetic testing for BRCA-1 and BRCA-2. This may impact some of the treatment decisions you make in the future.
REMS stands for risk evaluation and mitigation strategy.

The Food and Drug Administration (FDA) governs the REMS program. The purpose is to provide drug safety information to the public to improve transparency and communication. The manufacturer is required to disseminate information to be sure that patients are aware of both the benefits and risks of drugs.

This program was initiated in accordance with Section 915 of the Food and Drug Administration Amendments Act of 2007 (FDAAA).

Below are two websites that list the REMS strategies and give further information on REMS:
http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm111350.htm
http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/default.htm
Causes of hyperpigmentation, which is a more than normal pigmentation of the body, usually of the skin include:
- changes in hormones, pregnancy, or Addison's disease
- sun damage or sun exposure
- injuries
- a particular skin type
- acne
- medications, such as chemotherapy drugs.

The chemotherapy drugs are that may cause hyperpigmentation are Fluorouracil (5-FU), Cytoxan, Alkeran, Myleran, Bleomycin (Blenoxane), Adriamycin, Daunorubicin, and the topical treatment BCNU.

Generally, hyperpigmentation caused by chemotherapy is short-lived. The darkening of the skin usually slowly fades when the offending chemotherapy medication is discontinued.
The main examples of plant alkaloids used to treat breast cancer are taxanes and vinca alkaloids.
- The vinca alkaloid used to treat breast cancer is vinorelbine (trade name: Navelbine).
- The taxanes used to treat breast cancer are paclitaxel (trade name known as Taxol) and docetaxel (which is a semi synthetic analogue of paclitaxel known as Taxotere)
Foods to eat when you are experiencing nausea and vomiting are:
-Bland foods such as:
- Scrambled eggs, mashed potatoes, plain steamed rice, applesauce or pudding, water or juice, ginger ale, poached egg on dry toast, saltine crackers or bread sticks, clear broths, and jello.

- Foods to avoid are: fried foods, fatty foods, hot, spicy foods, greasy chicken noodle soup, fudgesicles, milk products and milk, strong smelling foods
Question by: JKJones (Pharmacist (Verified)) in topic(s) Bland Foods, Avoid Spicey Foods, Vomiting, Nausea, Avoid Milk & Milk Products, Avoid Fried Foods
Neupogen (Filgrastim) is used to treat neutropenia, which is a decreased quantity of white blood cells in the body. Neupogen assists in the growth of a type of white blood cell called neutrophils by stimulating the colonies of white stem cells within the bone marrow. By increasing the number of white blood cells in your body it helps your body fight infections. White blood cells are found within the bone marrow and grow fairly rapidly, therefore they are often damaged by chemotherapy.

To determine whether you have a low white blood cell count, your physician will check you blood work, also called CBC (Complete Blood Count) or WBC known as White Blood Count. The normal number of neutrophil is between 2500-5000. A low neutrophil count is below 1000 and this is known as neutropenia
The first step to overcoming iron-deficiency anemia is to eat a diet of iron-rich foods. Foods rich in iron are:
- liver, beef
- chicken,turkey
- oysters, shellfish, sardines
- broccoli, collards, and other leafy greens from cabbage family
- lima beans, legumes, peas, black-eyed peas, and baked beans
- iron-enriched bread, rice, cereals, pasta

Over-the-counter treatment may include:
- Iron supplements to correct the iron deficiency (it is better to take iron pills on an empty stomach if possible so that the iron may be absorbed more efficiently).
- Multivitamins as vitamin supplements
- Vitamin supplements like B12 and Folic acid.
- Vitamin C is important because it assists the body in the absorption of iron.

Prescription treatments may include:
- Intravenous iron therapy such as Iron Sucrose, Iron Dextran, Sodium Ferric Gluconate.
- Blood transfusions.
- ESAs (Erythropoiesis-stimulating agents help red blood cells grow in the body). They are Aranesp® (darbepoetin alfa), Epogen® (epoetin alfa), or Procrit® (epoetin alfa).
The ESA APPRISE Oncology Program is part of a Risk Evaluation and Mitigation Strategy (REMS) the Food and Drug Administration (FDA) has started. It has determined that REMS are necessary for ESAs to be sure that the benefits of these drugs outweigh the risks of shortened overall survival and/or increased risk of tumor progression or recurrence as shown in clinical studies in patients with breast, non-small cell lung, head and neck, lymphoid, and cervical cancers. The ESA APPRISE Oncology Program addresses those who are to receive an ESA for the Treatment of Anemia in patients with cancer and patients on Chemotherapy.

ESA is an erythropoiesis stimulating agent. These drugs are Procrit (epoetin alfa), Epogen (epoetin alfa), or Aranesp (darbepoetin alfa).

The Procrit/ Epogen/ ESA APPRISE QUESTIONNAIRE must be completed by a physician, nurse, or pharmacist prior to dispensing the drug. The completion of the questionnaire insures that the patient has been educated about these medications and has been informed of the advantages and disadvantages of these drugs.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Anemia, Epoetin Alfa, ESA APPRISE Oncology Program, Darbepoetin, Aranesp, REMS, Procrit
Foods to eat when you have diarrhea are:
- bananas have pectin which is a soluble fiber and bananas also have increased amount of potassium which replaces an important electrolyte.
- rice, white bread (dry toast), crackers, and mashed plain potatoes because they are low in fiber and digested without difficulty in the upper GI tract.
- drink lots of fluids including clear liquids such as water, apple juice, sports drinks, and teas such as peppermint and chamomile.
- steamed white meat of the chicken.
- cooked apples are a source of pectin, sugar, and nutrients.
- dried blueberries which are a source of soluble fiber and antioxidant, they contain tannins which may decrease loss of fluids.

Foods to avoid when you have diarrhea are:
- avoid dairy and milk products with the exception of yogurt with live cultures of Lactobacillus acidophilus and Bifidobacterium bifidum
- caffeinated beverages.
- sugar free foods and diet sodas.
- fatty foods.
- gas producing foods, such as beans, broccoli, or cauliflower.
- dairy products such as ice cream and cheese.
- alcohol.
Question by: murray (Family member) in topic(s) Side Effect, Diarrhea, Diet, Lactobacillus, Food, Nutrition
ESA APPRISE Oncology Program stands for Assisting Providers and Cancer Patients with Risk Information for the Safe use of ESAs. This is an educational oncology program for healthcare professionals who prescribe ESAs to patients with cancer. The FDA required the manufacturer to develop the ESA APPRISE Oncology Program.

The ESA APPRISE Oncology Program requires that:
- The prescribing physician must be enrolled in the ESA APPRISE Oncology Program.
- The pharmacy must receive a copy of the acknowledgment form that confirms that the physician is enrolled in the ESA APPRISE program, there has been a discussion about the risks of the ESA between the health care professional and the patient, and the patient has received and been counseled with the appropriate ESA medication guide prior to each new course of therapy.
ESAs stimulate the bone marrow to produce and generate red blood cells. ESAs are given to patients with chronic kidney failure and to patients on chemotherapy. The FDA approved the use of ESAs for the treatment of anemia, which is low red blood cells and low hemoglobin levels in the body.

Recently though, the FDA has decided to require more education for both the patient and physician before prescribing. This is because there is new evidence that ESAs cause shortened overall survival and increased risk. The FDA requires that ESAs be included on the REMS (Risk Evaluation and Mitigation Strategy) list. REMS is a medication guide which describes the risks and benefits of ESAs and must be provided to all patients receiving ESAs.

Initially FDA approval was given in order to reduce the number of blood transfusions these patients would require.

There are three erythropoiesis stimulating agents (ESAs):
- Procrit (epoetin alfa), Epogen (epoetin alfa), or Aranesp (darbepoetin alfa.
Unfortunately studies have not been done to directly compare the Aromatase Inhibitors. The side effects for these medications may be different from patient to patient.

Here are some of the differences between these medications:
- Differences in chemical structure.
- Aromasin is a steroidal compound.
- Femara and Arimidex are non-steroidal compounds.
- Aromasin is the newest aromatase inhibitor, therefore there is less scientific data about this medication.

Here are a couple of other articles on this subject:
http://www.breastcancer.org/news_research/ask_expert/2005_12/question_09.jsp
http://www.healthcentral.com/breast-cancer/c/78/17222/aromatase-faqs
Here are some options to consider:

1) Getting financial support for Femara. You may be eligible for financial support to help purchase Femara. One program specifically is the Femara Cares Program at http://femara.com. You may want to ask the community about other financial support programs.
2) Stay on Arimedex and treat the side effects. The medications to treat the side effects may improve your quality of life, but you will need to discuss their costs and side effects with your physician.
3) You may consider the other Aromatase Inhibitor, Aromasin (exemestane). Pfizer has a financial assistance program as well - http://www.pfizerhelpfulanswers.com/pages/misc/Default.aspx
4) Another alternative is Tamoxifen. Studies have shown that Aromatase Inhibitors are more effective in postmenopausal women with ER+ breast cancers, but if side effects are severe, Tamoxifen is an option to consider.

Here are a couple of articles comparing tamoxifen to aromatase inhibitors:
http://www.medscape.com/viewarticle/447550_2
http://www.sciencedaily.com/releases/2008/12/081211161737.htm
Anaphylaxis is a severe allergic reaction that is life threatening. A toxin is introduced to the body that our body has been sensitized to on earlier exposure and our immune system responds with an anaphylactic reaction. Immediate treatment is necessary.

Causes: Chemotherapy and other medications, food, insect bites or stings, environmental toxins, such as pollen, or animal dander.

Symptoms to watch for in an anaphylactic allergic reaction include the following:
- Difficulty breathing, wheezing, abnormal high pitched breathing sounds, coughing, and nasal congestion.
- Tongue, lips, and eyelids swelling.
- Fainting, dizziness, light headedness, confusion, slurred speech, and anxiety.
- Hives such as urticaria, raised, itchy blotches, skin redness.
- Abdominal pain, cramping, nausea, vomiting, diarrhea.
- Internal reactions include low blood pressure, shock, and death.

Treatment:
- Help prevent exacerbation by having the patient lie flat, do not raise the patient's head, lift the patient's feet, cover the patient, and do not give anything by mouth.
- Administer an epinephine pen if available.
- Treatment includes administering epinephine, intravenous cortisone and antihistamines, oxygen, and an albuterol inhaler to assist with the breathing.

Here are a couple of other sites with information on this:
http://www.nlm.nih.gov/medlineplus/ency/article/000844.htm
http://www.webmd.com/allergies/understanding-anaphylaxis-basics
Suggestions for replacing fluids are:
- Juices and sports drinks may be added besides water.
- Ice chips, flavored ices,frozen juices, and popsicles replenish fluids.-
- Dehydrating fluids, such as alcohol, caffeinated beverages such as sodas, coffee and tea should be avoided.
- Fruits and vegetables that have a high concentration of water are: Strawberries, tomatoes, Cucumbers, Squash, Eggplant, lemons, watermelons, raddishes, and dark leafy greens.
- Drinking 8-10 glasses that are 8 oz. each of fluids daily is essential.
- Drink all day especially between meals..
- An indicator that you are drinking enough fluids is if you are not thirsty and your urine is pale yellow.

Here are a couple of other websites that will give you more information:
http://www.livestrong.com/article/393215-list-of-water-content-foods/
http://www.ehow.com/list_6141521_foods-eat-dehydrated.html
Question by: JKJones (Pharmacist (Verified)) in topic(s) Juices, Flavored Ices, Sports Drinks, Frozen Juices, Popsicles, Tomatoes, Strawberries
Docetaxel (TAXOTERE®) is a chemotherapy medication. It is a "plant alkaloid," known as "taxane" and a "antimicrotubule agent."

Side effects of docetaxel are:
- Hematological: low white blood cell counts which may increase the risk of infection and low red blood cell counts which indicate anemia.
- Fluid retention and swelling in the ankles or belly area.
- Numbness and tingling in your extremities known as neurosensory reactions.
- Nausea, diarrhea, mouth sores, and taste changes.
- Loss of your hair
- Tiredness and weakness which may be linked to low red blood cells.
- Infection due to diminished white blood cells in the body.
- Changes in your nails including color changes and in rare cases the nails may fall off, which will grow back when the therapy is stopped.
- Changes in your liver function.
- Be watchful for an allergic reaction.
- Injection site discomfort.

If you experience unusual symptoms, please consult your physician.

Here are a couple of reference sites:
http://www.taxotere.com/oncology/ESBC/safety_profile.aspx#AE
http://en.wikipedia.org/wiki/Docetaxe
Question by: JKJones (Pharmacist (Verified)) in topic(s) Taxotere (Docetaxel), Side Effects
A side effect is an undesirable response in your body when a medication is given.

- May be a mild or a severe response by the body.
- May occur when the medication is started or when treatment regimen has stopped.
- A side effect can be addressed and managed. Changes in lifestyle or dietary changes may help decrease the unwanted side effect as well as medication.
- A side effect may be long term or short term.
- Each person will respond differently to a medication therefore the side effects will occur or not occur.

In conclusion, side effects are a secondary effect of the medication in addition to the therapeutic desired effect of a medication. Each person's response to a medication will be different and the response will depend on the disease, age, weight, gender, ethnicity, and general health and well-being.

Here are a couple of references for this question:
http://www.chemocare.com/whatis/what_are_the_short_and_long_term.asp
http://www.drugs.com/sfx/
It is believed that Abraxane is more effective at treating tumors than Taxol for the following reasons:
- Higher doses of paclitaxel can be delivered without the need for solvents.
- A higher percentage of the paclitaxel reaches the tumor because albumin receptors in breast cancer cells prefer albumin as their delivery packet because albumin normally transports nutrients to cells.

Additionally, Abraxane
- has decreased side effects due to solvent related (polyoxyethylated castor oil found in Taxol) hypersensitivity reactions.
- decreased use of medications to help prevent the solvent (polyoxyethylated castor oil) hypersensitivity reactions.
- The intravenous time of administration is decreased.

Here are a couple of more resources on abraxane:
http://www.medscape.com/viewarticle/465645
http://www.webmd.com/breast-cancer/features/new-treatments-for-breast-cancer?page=1%20&%202
Question by: JKJones (Pharmacist (Verified)) in topic(s) Paclitaxel, Albumin, Solvent Polyoxyethylated Castor Oil, Onxal, Taxol, Abraxane
Hives, also known as urticaria, are flat topped bumps, called wheals or welts, that swell and are redder than the surrounding skin and itchy. The welts vary in size and may join together and form larger areas. Unique to hives is the fact that they change shape, go away, and then crop up later on different parts of the body. Hives may appear suddenly. Hives are caused by insect bites, medications, or foods and are the result of the release of histamine from cells in the skin. Hives usually last 24 hours.

Hives around the face, especially the lips and eyes, is called angiodema. Swelling from angioedema may also be seen in throat, hands, and feet.

Hives may be the first sign of an anaphylactic reaction, which is a severe allegic reaction that is life threatening. If any of the following symptoms appear after hives, seek emergency treatment immediately: shortness of breath, difficulty swallowing, your tongue swells, nausea, weakness, and confusion.

Here are a couple of other resources on hives:
http://www.nlm.nih.gov/medlineplus/ency/article/000845.htm#Definition
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001848/
Benefits of Abraxane vs. Taxol or Onxal are:
- more effective at treating tumors because a higher dosage can be delivered.
- decrease in side effects from solvent related hypersensitivity reactions.
- decreased use of medications to combat the solvent related hypersensitivity reactions.
- decreased time of administration.

The disadvantage is that the Abraxane is more expensive than the Taxol or Onxal.

Here are a couple of more resources on abraxane:
http://www.medscape.com/viewarticle/465645
http://www.webmd.com/breast-cancer/features/new-treatments-for-breast-cancer?page=1%20&%202
Question by: JKJones (Pharmacist (Verified)) in topic(s) Paclitaxel, Albumin, Advantages Of Abraxane, Onxal, Disadvantage Of Abraxane, Abraxane, Taxol
Paclitaxel is the active drug in Taxol and Abraxane. The difference between Taxol and Abraxane is that they use different formulations to deliver paclitaxel to the body. Specifically, Taxol contains paclitaxel dissolved in polyoxyethylated castor oil. In contrast, in Abraxane, paclitaxel is encapsulated in albumin, a human protein.

Here are a couple of more resources on abraxane:
http://www.medscape.com/viewarticle/465645
http://www.webmd.com/breast-cancer/features/new-treatments-for-breast-cancer?page=1%20&%202
Question by: JKJones (Pharmacist (Verified)) in topic(s) Paclitaxel, Human Protein, Albumin, Abraxane, Taxol
Losing your hair is a distressing, devastating, and a life altering event.
- Loss of hair does not occur with all chemotherapy treatments, so please check with your physician if your medication will cause alopecia (hair loss).
- Hair is lost because chemotherapy agents affect all your body's cells as well as the cancer cells, especially the fastest growing cells.
- Be gentle with your scalp using soft brushes, comb gently, and use mild shampoos.
- It usually occurs a few weeks after the beginning of your chemotherapy.
- Hair loss may be occur rapidly or slowly or fall out in clumps.

Be prepared and start an action plan to decide what option is best for you and what you are most comfortable with:
- Beauticians may cut your hair really short.
- Purchase a wig; maybe more than one wig, maybe in a different hair color (some insurance companies will pay for a wig if the physician will order for "cranial prosthesis;" or the cancer societies have assistance programs). Hair stylists will style the wig to your specifications.
- Purchase caps, hats, and scarves. With the scarves be sure to learn how to tie them in unique ways.
Realize:
- At the completion of your treatment your hair may grow back with a different texture, color, etc.
- It may take 3-6 months after the completion of your chemotherapy for your hair to grow back.
Question by: murray (Family member) in topic(s) Chemotherapy Side Effects, Alopecia, Hair Loss And Changes, Chemotherapy
One of the doctor's main tasks is to formulate a treatment regimen that is the best fit for you. Here are options you may discuss with your physician:

You may be able to try other aromatase inhibitors, such as Femara or Aromasin. These drugs may have different side effects that you'll find more tolerable. Before following this path, your doctor will evaluate your breast cancer case as a whole including your medical history.

As your doctor mentions, you may take medications to help alleviate the current side effects from Arimidex. This may be worth a try for a short period of time to see how you react.
Question by: raysingboyz (Current Patient) in topic(s) Insomnia, Arimidex (Anastrozole), Joint Pain, Side Effects
Some tips to help deal with the rash from Docetaxel (Taxotere):
- Shower in lukewarm water with a mild soap containing no perfume to reduce irritation and pat dry.
- Don’t rub your skin and avoid scratching.
- Wear loose clothes made of cotton, tight clothes can rub and irritate a rash.
- Protect your skin with clothing and sunscreen when outdoors.
- Stop using perfumes, perfumed body lotions, as well as powders, body oils, and creams that could make the rash worse.
- It is important to also protect your nails. Wearing gloves is advised especially during chores.

Over the counter treatment options that may help include:
- Hydrocortisone cream (Cortisone).
- Diphenhydramine cream (Benadryl) for itching.

Prescription options may include:
- Stronger steroid creams to alleviate itching.
The natural form of folic acid (folate) is not absorbed in the body as well as the man made form of Folic acid, therefore the Food and Nutrition Board of the Institute of Medicine recommends these daily requirements of man made Folic Acid for women:
- women in the childbearing years should take 400-800 micrograms of Folic acid daily.
- older women (not able to get pregnant) should take 400 micrograms of Folic Acid daily.

It is important for women's health to meet the daily requirements of Folic Acid. Folic acid helps women to stay healthy, aids in the prevention of cancer and heart disease, as well as protects against birth defects. Folate or folacin is a member of the family of B vitamins and it is Vitamin B9. Folate comes from green leafy vegetables, citrus fruits, beans, and whole grains.
Question by: murray (Family member) in topic(s) Women, Folic Acid, Daily Requirements, Pregnancy
The natural form of folic acid (folate) is not absorbed in the body as well as the man made form of Folic acid, therefore the Food and Nutrition Board of the Institute of Medicine recommends these daily requirements of man made Folic Acid for men:
- A supplemental dose of 400 micrograms of Folic acid daily is needed.*

* This recommendation meets the food and vitamin requirements for 97-98% of healthy people in each age and gender group.

Folate or folacin is a member of the family of B vitamins and it is Vitamin B9. Folate comes from green leafy vegetables, citrus fruits, beans, and whole grains.
Question by: murray (Family member) in topic(s) Folic Acid, Daily Dose, RDA, Men
As a consequence of chemotherapy medications and the side effects of the treatment, body fluids are lost. It is extremely important for your health that you replenish these fluids.

The general daily recommended intake of fluids is 9 cups for women and 13 cups for men. As well, in addition to this daily amount, it is recommended you drink 8 ounces of fluid for every time you vomit or experience diarrhea.

A couple of common ways we lose excess fluids may be vomiting and diarrhea. I recommend keeping a daily record estimating how much fluid you are losing from urinating, vomiting and diarrhea relative to a normal day. You should replace the extra fluid you lose in addition to the 9-13 cups needed to fulfill your daily requirement.

Some suggestions for fluids that you may drink are:
- water
- juices and sports drinks
- ice chips, flavored ices, frozen juices, and popsicles

You should avoid dehydrating fluids such as alcohol and caffeinated beverages (sodas, coffee and tea).

Tips to make sure you drink enough are:
- Drink all day especially between meals.
- Take a bottle of water wherever you go

An indicator that you are drinking enough fluids is if you are not thirsty and your urine is pale yellow.

If your physician is worried about dehydration due to vomiting and diarrhea, medications may be prescribed to treat these side effects.
Hives are patches of edema (swelling) that occur on the skin surface. Hives are swollen areas of the skin that are red and itch. Hives may change shape, go away, and reappear. Hives commonly appear in the upper arms, legs, neck, and sides of the body.

Treatment
- For mild symptoms treatment may not be needed
- Avoid the offending agent causing the hives
- Cool soaks

- Over the counter treatment includes
- Antihistamines topically or orally;
- Anti-inflammatory medicines (corticosteroids such as hydrocortisone cream topically or oral agents)

For moderate to severe symptoms which include breathing difficulty, emergency treatment should be initiated.
Epi-pen (Epinephrine) may be administered.
Edema is abnormal retention of fluid in your body.

Symptoms include:
- After walking or standing your feet and legs appear swollen and skin appears stretched and shiny (especially at the end of the day)
- Shoes feel unusually tight
- When you make a fist, your hand feels abnormally tight.
- The ring on your finger is too tight
- Stomach or abdomen is swollen
- When you remove your socks there is an indentation from the elastic that remains there longer than normal
- There is swelling or puffiness under your skin and when you press on your skin a dimple remains which is slow to disappear.

It is important to contact your physician if:
- Experience difficulty breathing, rapid breathing, or shortness of breath
- If you urinate a small amount or none at all
- Gained more than 5 pounds in a week or short period of time
- Chest pain
- When touching your hands and feet they feel cold
Excess fluid beneath the skin is called edema. It is most prevalent in the feet, ankles, hands and face, but edema or swelling may also appear in other parts of the body. The accumulation of fluid may be from chemotherapy treatment, cancer surgery, heart failure, or an allergic reaction.

Other causes might be:
-Too much salt in the patient's diet
-Blockage of lymph system, especially after a mastectomy or surgery
-Heart failure, kidney or liver problems
-Excessive standing, walking, exercising in warm weather and sun exposure (resulting in sunburn)

To reduce the swelling:
- limit the amount of salt you eat
- when sitting, raise your legs and hands
- wear support stockings
- your physician may prescribe a diuretic (water pill)

If you notice swelling in your throat, tongue, lips, eyelids or airway, this may be an allergic reaction which could result in suffocation. It is important to seek aid immediately.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemotherapy Side Effect, Side Effect, Edema, Swelling Of Skin, Swelling
Common causes of dehydration are:
- extra and prolonged loss of body fluids
- excessive vomiting
- prolonged diarrhea
-inadequate amount of fluid is ingested
-excess or strenuous exercise
-fever
-overuse of diuretics or laxatives
Question by: JKJones (Pharmacist (Verified)) in topic(s) Vomiting, Laxatives, Diarrhea, Dehydration, Diuretics, Loss Of Body Fluids
Good blood pressure, also medically stated as normal blood pressure, has two readings which are known as systolic blood pressure over diastolic blood pressure as a fraction. The normal systolic blood pressure range is 90-119 mmHg; the normal diastolic range is 60-79mmHg.

- systolic blood pressure is defined as: the pressure inside your blood vessels at the moment your heart beats.
- diastolic blood pressure is: the measurement of the pressure in your blood vessels between heartbeats, when your heart is at rest.
- blood pressure is measured in mmHg by a sphygmomanometer which measures a unit of pressure equal to the amount of fluid pressure one millimeter deep in mercury at zero degrees centigrade on Earth.
Scientific studies have shown that tamoxifen reduces the occurrence of estrogen-receptor-positive cancers, but there is no difference in the outcomes for estrogen-receptor-negative cancers.

Tamoxifen is not effective against hormone-receptor-negative breast cancer because hormone-receptor-negative breast cancer (as the name states) does not have hormone receptors.

However, there are other studies to take into consideration regarding tamoxifen and hormone-receptor-negative breast cancer, but none are conclusive.

- A study at University of Texas M.D. Anderson Cancer Center that reduced the diagnosis time of estrogen-receptor-negative breast cancers in patients taking tamoxifen.
- A study at Fred Hutchinson Cancer Research Center indicated that tamoxifen may result in increased chance of developing hormone-receptor-negative cancer.

http://www.breastcancer.org/treatment/hormonal/new_research/20081007.jsp
http://www.cancer.gov/cancertopics/factsheet/Therapy/tamoxifen
http://www.news-medical.net/news/20090826/Tamoxifen-drug-poses-increased-risk-of-developing-ER-negative-breast-cancer.aspx
Question by: JKJones (Pharmacist (Verified)) in topic(s) Hormone Receptor Negative Breast Cancer, Treatments, Nolvadex (Tamoxifen)
Folic acid is the man-made form of folate. Folate is essential and needed by everyone. Folate belongs to the family of B vitamins and it is a water-soluble vitamin. Folate is vital for the synthesis and production of red and white blood cells.

Folate plays a vital role in preventing diseases, such as heart disease, stroke, depression, cancer, diabetes, anemia, macular degeneration, and so on.

Some people who need folic acid are:
- In infancy because there is rapid cell growth and division.
- If you are planning for pregnancy, pregnant, or breast feeding.
- If you often consume more than one alcoholic drink per day.
- Certain medications may cause a depletion of folic acid.

For a diet that is not well balanced and does not include the foods listed below, Folic Acid 400 microgram tablets may be purchased over the counter at your local pharmacy.

Excellent sources of folic acid include:
- Grain products such as whole wheat, fortified flour, fortified cereals
- In meat and beans, such as eggs, beans, sunflower seeds, black-eye peas, great northern beans, legumes and liver
- Vegetables are an excellent source, such as asparagus, green peas, broccoli, and leafy green vegetables.
- Fruits such as oranges, strawberries, cantaloupes, and other melons.

http://ods.od.nih.gov/factsheets/folate/
http://ohioline.osu.edu/hyg-fact/5000/5553.html
http://www.womenshealth.gov/faq/folic-acid.cfm#a
Question by: glenmjones (Survivor (10 - 20 years)) in topic(s) Folic Acid, Vitamins
Studies thus far are inconclusive as to whether taking Vitamin C cures, prevents, speeds recovery, or reduces the severity of the symptoms of the common cold.

Most studies have found that taking Vitamin C has no overall noticeable benefit for preventing or treating the common cold.

However, people living in extreme conditions or people under extreme circumstances have reported a 50% reduction in the risk of contracting a cold. The extreme conditions and circumstances include soldiers in sub-arctic exercises, skiers, and marathon runners. This evidence needs to be further investigated to verify these claims.

http://www.umm.edu/altmed/articles/vitamin-c-000339.htm
http://www.webmd.com/cold-and-flu/news/20070717/vitamin-c-cant-cure-common-cold
http://www.independent.co.uk/life-style/health-and-families/health-news/vitamin-c-does-not-protect-against-the-common-cold-457707.html
http://www.newsweek.com/2007/11/14/can-vitamin-c-cure-colds.
http://www.mayoclinic.com/health/vitamin-c/NS_patient-vitaminc
http://www.mayoclinic.com/health/vitamin-c/NS_patient-vitaminc/DSECTION=evidence
Question by: glenmjones (Survivor (10 - 20 years)) in topic(s) Common Cold, Headaches, Sore Throat, Runny Nose Treatments, Vitamins, Cold Symptoms, Runny Nose
Here are four physicians in the area that you may want to connect with to interview and determine if they are a good match for you.

- Dr. Maen Hussein practices hematology, oncology and internal medicine in Lady Lake, Leesburg, and Tavares, Florida. http://www.healthgrades.com/directory_search/physician/profiles/dr-md-reports/dr-maen-hussein-md-b64338ec
- Dr. Imad El-Jassous practices hematology in Lady Lake and Leesburg, Florida. http://www.vitals.com/doctors/Dr_Imad_El-Jassous.html
- Dr. William Grow practices hematology, oncology and internal medicine in Orlando, and Winter Park, Florida. http://www.vitals.com/doctors/Dr_William_Grow.html
- Dr. Rakesh Rohatgi practices hematology, oncology and internal medicine in Lady Lake and Ocala, Florida. http://www.vitals.com/doctors/Dr_Rakesh_Rohatgi.html

On the following websites: www.HealthGrades.com and www.Vitals.com you may check these physician's education, office locations, patient evaluations, and other pertinent information.
Live chat by: member5382 (Friend) in topic(s) Lady Lake, Recommendations, Florida, Oncologist
Actions to manage edema include:
- Try to keep your feet elevated, do not stand for long periods of time, and do not cross your legs while sitting.
- Consider sleeping with a pillow under your feet and lower legs
- Wiggle and exercise your feet, toes, and lower extremities during times of sitting or extended times of standing
- Consider exercising 3-5 days a week
- Avoid tight clothing (shoes, girdles, etc).
- Avoid extreme temperatures such as hot baths
- Try to watch your salt intake and avoid salty foods such as ham, processed food, canned soups, chips, french fries, and consider reducing trans fatty acids such as margarine and use olive oil instead.
- Eat diuretic vegetables such as asparagus, parsley, beets, grapes, green beans, leafy greens, pineapple, pumpkin, onion, leeks, and garlic
- Avoid tobacco and alcohol
- With permission from your physician you might consider wearing support stockings or hose.
- Consider weighing yourself often and inform if your physician it you gain weight and have trouble breathing. (A significant amout is 5 pounds or more in a week.)
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemotherapy Side Effect, Edema, Managing Edema, Side Effects
To treat edema, it is important to treat the underlying cause. But if the cause can not be treated, the physician might recommend a treatment plan including a diuretic.

Diuretics are known as "water pills" as they work by making you urinate excess fluid. Some examples of these medications are furosemide (Lasix), Torsemide, Butethamine, metolazone and Hydrochlorthiazide. You may receive this medication alone or in combination with other medications.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemotherapy Side Effect, Side Effect, Edema, Swelling Of Skin, Swelling
Different treatments for relieving pain from mouth sores include:
Over the counter agents include:
- Throat lozenges and throat sprays such as Cepacol and Sucrets (dyclonine)
- Swishing and gargling preparations include Biotene mouthwash (which has enzyme protection with moisturizers), Chloraseptic mouthwash, Chamomile tea
- A dental gel, such as Oral Balance which contains enzymes and moisturizers
- Adhesive paste Orabase B contains the topical anesthetic (benzocaine)
- Over the counter anesthetics, such as Xylocaine, Anbesol or Orajel (contains benzocaine)
- Ulcerease rinse
- Benadryl elixir without alcohol
- Swishing Mylanta or Maalox in the mouth may relieve discomfort
- Over the counter pain relievers such as ibuprofen and actaminophen

Make sure to keep your physician informed of any product you use.

Prescription products include:
- Gelclair is an oral gel designed to coat and soothe mouth sores by forming a protective barrier in the mouth.
- Peridex mouth wash
- Mugard (Mucoadhesive Oral wound rinse)
- Or your physician might prescribe a combination triple medication mouth wash with varying medications. An example might be a GI Cocktail: 1 tbsp (15mL) Cherry Maalox (acid reducer) + 1 tsp. (5mL) + Nystatin (antifungal) + 1/2 tsp. (2mL) xylocaine viscous (analgesic). Mix ingredients thoroughly. Swish and gargle for one minute, and then swallow immediately before each meal.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Mouth Gels, Mucositis, Throat Lozenges, Side Effects, Mouth Sores, GI Cocktail, Mouth Rinses, Pain Relief
To help prevent or minimize mucositis from chemotherapy here are some suggestions:
-chew or suck on ice chips or popsicles before and during chemotherapy
-Maintain safe oral hygiene using a soft-bristle toothbrush with a non-abrasive toothpaste after meals and at bedtime
-Keep lips moistened with vaseline free moisturizers
-Stay hydrated
-Maintain a good nutritional diet
-It is important to avoid mouth washes with alcohol and limit the use of dental floss
-Swishing and spitting with home remedies such as Normal saline (1 tsp of salt to 32 oz.of water) or Salt and Soda (one-half tsp of salt and 2 tbsp of sodium bicarbonate in 32 oz. of warm water)
-Caphosol mouth rinse (Artificial Saliva)
-MuGard mouth rinse
-Prevention Oncology Mouth Rinse
-Over the counter ranitidine or omeprazole reduces stomach acid stopping epigastric discomfort that might irritate the mouth sores.
-Prescription mouthwashes include Peridex® or Periogard®
Question by: JKJones (Pharmacist (Verified)) in topic(s) Mucositis, Oral Sores, Oral Mucositis, Side Effects, Mouth Sores, Treatments, Mouth Washes
To give encouragement and hope to your friend is vital and you both need to remember to stay upbeat, research all the possibilities, and remember that life is a journey. Here are a couple of things you may say:

“We can be so thankful that the breast cancer was discovered, so now we as part of your team can do something about it.”

“It is a scary diagnosis, but you have control over the course it will take, control over stressful times, and control over your state of mind. We have the power to stay informed, too. It is important to treat your mind first and the disease second.”

On a personal note my mother always said to me what Mother Teresa said, I know God will not give me anything I can't handle. I just wish that He didn't trust me so much.
Common symptoms of a mild allergic reaction include:
- Hives (especially over the neck and face) and itching
- Nasal congestion
- Rashes
- Watery, red eyes

Symptoms of a moderate or severe reactions include:
- Difficulty breathing, swallowing, wheezing, chest discomfort or tightness
- Swelling of the face, eyes, or tongue
- Dizziness, light-headedness, weakness
- Flushing or redness of the face
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Symptoms, Allergic Reactions, Watery, Hives, Rashes, Red Eyes, Allergic Reaction Symptoms
Here are some habits to form to help deal with depression:
- As hard as it may be, the important thing to do is get out of bed and get going.
- Exercising is important. Find a friend to exercise with, join a wellness center, an exercise gym and devote at least 4 times a week or more.
- Decide what you have always wanted to learn to do, such as hobbies, classes, and so on and sign up.
- Eat healthy and get a good night sleep.
- It is important to change your attitude to be more positive and develop friendships with positive people. Replace sad thoughts with positive ones.
- Use positive affirmation.
- Make decisions and try not to procrastinate. Don't think about what you are going to do, just do it.
- Volunteer at an organization or help someone. This may make you feel better as well as help someone else.
- Consult your physician with your symptoms. Physicians may prescribe antidepressant medication.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Unable To Get Up In The Morning, Lethargy, , Sadness, Tiredness, Depression, Blackness In Mind
Cancer treatments (chemotherapy, radiation, surgery) may result in late side effects (side effects that appear after treatment has ended). Some examples are:

Chemotherapy
- Cataracts
- Infertility
- Liver problems
- Lung disease
- Reduced lung capacity
- Osteoporosis
- Secondary primary cancers

Radiation therapy
- Cataracts
- Cavities and tooth decay
- Heart problems
- Hypothyroidism
- Infertility
- Lung disease
- Intestinal problems
- Memory problems
- Secondary primary cancers

Surgery
- Lymphedema
Chemotherapy, surgery, and radiation may cause long-term side effects. Some examples are:

Chemotherapy:
- chronic fatigue
- neuropathy
- chemobrain
- symptoms of menopause
- liver problems
- heart failure
- kidney failure
- infertility

Radiation therapy
- fatigue
- skin sensitivity

Surgery
- scars
- chronic pain
Side effects may be classified in three ways:
- Acute (short-term) effects occur during chemotherapy. These are nausea, vomiting, diarrhea, head aches and so on.
- Chronic (long-term) side effects occur during chemotherapy and may or may not be permanent. Some examples include chronic fatigue, liver problems, and heart failure.
- Late effects (also called long-term late side effects) appear a few weeks after the treatment has ended to even few years after the treatment. There is no way to tell if or when these side effects will appear. Some examples include cataracts, heart problems, infertility, etc.
Breast radiation treatment hurts both the cancer cells and the healthy cells.

The two primary side effects of radiation treatment in breast cancer are:
- Fatigue
- Changes in your skin (dry skin, itchy skin, redness, peeling and blistering).

It is important to take care of your skin during treatment. Lotions and creams are available to apply to relieve the discomfort.

Side effects usually disappear about 2 months after the completion of radiation therapy.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Radiation Side Effects, , Radiation Treatment, Side Effects, Breast Radiation Treatment
Some anti-depressant medications interfere with the action of Tamoxifen, therefore inhibiting its effectiveness. This may result in an increased chance of breast cancer recurrence. The following medications for depression are potential options your physician may consider if you are also taking tamoxifen, but make sure to double check the latest research on this issue.
Venlavaxine (Effexor)
Citalopram (Celexa)
Escitalopram (Lexapro)
Sertraline (Zoloft)

This conversation has more details on this issue:
http://talkabouthealth.com/warning-some-depression-medications-inhibit-the-effectiveness-of-tamoxifen-cyp2d6-enzyme-and-depression-medication-caution.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Drug Interactions, Medications, Depression Medications, Nolvadex (Tamoxifen)
Quite a few breast cancer treatments may contribute to depression. Here are some:

- chemotherapy
- hormonal therapy:
- Arimidex (anastrozole)
- Aromasin (exemestane)
- Femara (letrozole)
- tamoxifen
- Evista (raloxifene)
- Fareston (toremifene)
- Faslodex (fulvestrant)
- ovarian shutdown or removal medications

Some pain medications, especially opiates, can cause depression.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Breast Cancer Medications, Pain Medications, Depression, Side Effects
Some of the antidepressant medications the physician might prescribe are:

- Citalopram (Celexa)
- Fluoxetine (Prozac)
- Paroxetine (Paxil)
- Sertraline (Zoloft)
- Amitriptyline (Elavil)
- Imipramine (Tofranil)
- Nortriptyline (Pamelor)
- Excitalopram (Lexapro)
- Venlafaxine (Effexor)
- Duloxetine (Cymbalta)
- Bupropion (Wellbutrin)
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Medications, Antidepressants, Depression, Depression Medications
The symptoms of clinical depression include:

- inability to cope - not able to make everyday decisions
- overwhelming feeling of helplessness and hopelessness
- not wanting to move or get up
- inability to concentrate
- memory problems
- panic attacks
- weeping and crying
- loss of pleasure in what used to make you happy
- lack of interest in sex or food
- sleep problems
- thoughts of death and/or suicide
- decreased energy, fatigue
- restlessness, irritability
- physical symptoms that do not respond to treatment such as chronic pain, headaches, and digestive disorders

First and foremost it is crucial to determine if you are clinically depressed or suffering from fatigue and sadness.

Sadness is a normal emotional feeling and part of life. Sadness may turn into depression. Be aware of being sad for too long and experiencing other symptoms of depression.

Fatigue is the feeling of tiredness and lack of energy. It is usually short lived. If it last longer than 2 weeks, you should inform your physician. Also watch out for other symptoms of depression.

Breast cancer diagnosis and treatment causes significant anxiety and stress, which may result in sadness, fatigue, or depression. This is a natural response. If a person is having difficulty with regular daily life activities for more than a couple of weeks and experiencing any of the above symptoms, they should notify their physician.
Symptoms of neuropathy include:
- pain, tingling, burning, numbness, loss of touch, and change in sensitivity to temperature in fingers, toes, arms, hands, legs, or feet
- constipation
- balance problems, difficulty walking, and weakness
- hearing loss
- jaw pain

People may begin to notice tingling and numbness in their fingertips and toes. The feelings gradually move to the hands and feet and the rest of the body. The bowels may also be affected resulting in constipation

If you suspect neuropathy please consult your physician and share your symptoms.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemo Side Effects, Numbness, , Neuropathy, Burning, Nervous System, Side Effects, Feeling Weak, Tingling
Here are some suggestions for dealing with neuropathy:
- Because of the side effect of loss of feeling, patients are prone to accidents and should be extra careful when cooking, in slippery areas, and in dark places.
- Keep the area with the symptoms warm and avoid extreme temperatures
- Good skin care and watch for cuts and burns
- Massage and physical therapy
- Make sure your diet includes the essential vitamins and minerals
- Stop smoking and exercise to improve circulation
- Moderate your alcohol intake
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemo Side Effects, Numbness, , Neuropathy, Burning, Side Effects, Nervous System, Tips, Feeling Weak, Tingling
When a physician treats neuropathy caused by cancer treatments, they treat the pain symptoms as well as prevention from worsening.

Pain relief options include:
- Over the counter - pain patches, topical creams, tylenol, etc.
- Prescription medications that might be effective are anti-seizure medications, lidocaine patch, and anti-depressants

Potential options to prevent the neuropathy from worsening are:
- If the medications are the cause, switching chemotherapy medications or dosage may be considered
- If a tumor is causing the problem, the tumor may be treated
Neuropathy can be caused by the following treatments for breast cancer:
- certain chemotherapy medications - toxins from the treatments damage the nerves
- radiation therapy - radiation damages the nerves
Neuropathy is damage to your peripheral nervous system, which may effect the skin, internal organs, or muscles.

For cancer patients, chemotherapy treatments may result in neuropathy. The symptoms, if they appear, usually increase gradually and may worsen as chemotherapy treatments continue. The symptoms may be the worst months after the treatments are completed. Neuropathy may be permanent, either the symptoms stay constant or diminish in severity, or eventually disappear. It may take months for the symptoms to resolve.

If the skin is affected, the symptoms are tingling, numbness, burning, sensitivity to touch, or freezing. People may notice these feelings in their fingertips and toes. The feelings gradually move to the hands and feet and the rest of the body.

If the internal organs are affected, the symptoms are constipation, bladder problems, dizzyness, or sexual dysfunction.

If the muscles are affected, the symptoms are weakness, cramping, spasms, and balance.
Do your best to avoid scratching and itching.
Don’t rub your skin.
Shower in lukewarm water with a mild soap and pat dry.
Wear loose clothes.
Wash with mild soap that contains no perfumes to reduce irritation.
Protect your skin with clothing and sunscreen when outdoors.
Stop using deodorants, body lotions, powders, body oils, and creams with perfumes as well as perfumes.

Hydrocortisone cream or anti-itch cream (diphenhydramine - benadryl) may be purchased over the counter.

Or your physician may prescribe a stronger steroid cream to alleviate itching.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Itching, Chemo Side Effects, Gemzar, Pruritis, , Side Effects
Fatigue is one of the most common side effect of breast cancer treatment. This side effect may appear at any time during the treatment. Rest does not alleviate the feelings of tiredness and fatigue. Fatigue may also continue after the treatments have ended.

To fight fatigue, it is important to exercise. Exercising 4 hours a week is recommended. You may find exercise partners at your support group, with friends, or fellow breast cancer survivors. You may also join a wellness center or gym and even get a personal trainer. This will improve your quality of life and physical fitness.

It is important to rest and eat properly along with drinking plenty of water and staying hydrated because your body is fighting the death of cancer cells (and healthy cells). Hydration assists metabolism. Your diet should include fruit, vegetables, and whole grains along with vitamins and minerals. Try to eat 15 calories a day for each pound you weigh. Eat several times a day, including nutritious snacks to boost your calories and protein intake. Good snacks are raisins, cranberries, apricots, yogurt, string cheese, carrots, vegetables, and prepackage energy bars. Liquid nutritional supplements such as Ensure come in different flavors and these provide extra calories and energy boosts. Protein assists in rebuilding the cells in your body and helps in the healing process.

Keep to a routine of when you eat and exercise. Exercise when you feel most energetic. Take naps when you need them as well.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemo Side Effects, , Side Effects, Fatigue
Dizziness may be described in two ways, vertigo or light headedness. It is important to differentiate between them. If you experience either though, you should share your symptoms to your physician.

Vertigo is the sensation that the room or your surroundings are whirling or spinning. This may be caused when your sensory nerves send incorrect signals to and from your brain.

Light headedness or wooziness is a feeling that you may faint, but you do not feel as if you or your surroundings are moving. Light headedness usually is a result of a lowering of your blood pressure or not enough blood flow to your head when you get up too quickly from a chair or out of bed. This might be a result of dehydration. It is a feeling of weakness or unsteadiness.

Chemotherapy may cause the side effect of dizziness. Some medications that might have this side effect are faslodex, femara, and fareston.

Here are some tips that may help if you are feeling dizzy: drink lots of fluids, try not to make quick movements, keep a telephone near in case you fall, keep the floors clear of clutter, and your living area well lighted.

Medications that may be prescribed for vertigo are meclizine, dramamine, and scopolamine patch.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Wooziness, Lightheadedness, Chemo Side Effects, Dizziness, , Vertigo, Side Effects
Potential treatments for unexplained bruising are:
- apply ice to the bruised area for about 20 to 30 minutes. This will help to constrict, or shrink the blood vessels that may be damaged and bleeding.
- heated compression (heating pad or warm wash cloth), 2 or 3 times a day, to help reabsorb the blood.
- Acetaminophen (Tylenol) for pain, up to 4000 mg per day which is maximum dose.

If you experience unexplained bruising, contact your physician and do not take non-steroidal anti-inflammatory (NSAID) drugs such as ibuprofen and aspirin unless the doctor suggests or states it is okay to take these medications.

Be sure to tell you doctor about any medications, vitamins, or herbal remedies you are taking as well as other disease conditions.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemo Side Effects, Bruising, , Unexplained Bleeding, Side Effects, Treatments
Neulasta and neupogen are similar molecules.

The primary difference is that Neulasta has a PEG (polyehtylene glycol) incorporated in its composition, thereby lengthening its duration of action. As a result, Neulasta is administered on a less frequent schedule. It is typically injected once for each cycle of high-dose chemotherapy 24 hours after chemo and no sooner than 14 days before your next chemo treatment.

Neupogen is typically injected on a daily basis until your neutrophil counts come back to normal levels. Neupogen may work fine with just weekly chemo treatments or it may be given as often as you need between chemo cycles.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Neutropenia, Pegfilgrastim, Neupogen, Filigrastim, , White Blood Cell Counts (WBC), Medications, Neulasta
These medications are prescribed for breast cancer patients who are at risk of decreased number of neutrophils (type of white blood cell) from the cancer or specific treatment
Question by: JKJones (Pharmacist (Verified)) in topic(s) Neutropenia, Pegfilgrastim, Neupogen, Filigrastim, , White Blood Cell Counts (WBC), Medications, Neulasta
Common side effects of Neupogen (Filigrastim) are:
- redness, swelling, bruising, itching or a lump in the location where the medication was injected
- bone, joint, or muscle pain
- headache
- nosebleeds

The following potential serious side effects should be reported to your physician: fever or chills, unhealed sores, swelling of extremities, difficulty breathing such as shortness of breath or trouble breathing, or chest pain and palpitations.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Neutropenia, Pegfilgrastim, Neupogen, Filigrastim, , White Blood Cell Counts (WBC), Side Effects, Neulasta
Here are some symptoms to look for if you think you may have an infection:
- Fever that is 100.5° F (38° C) or higher.
- Low body temperature, including chills.
- Cough or sore throat
- Ear pain
- Headache or bad sinus pain, pain behind your eyes
- Stiff or sore neck
- Bloody or cloudy urine, pain or burning when you urinate
- Sores or white coating in your mouth or on your tongue
- Skin rash, swelling or redness anywhere

Notify your physician right away of any of these symptoms.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Fever, Low Temperature, , High Temperature, Infection
Medications your doctor may consider prescribing for lack of appetite depending on your specific case:
- Megestrol acetate (Megace)
- Metoclopramide (Reglan)
- Dronabinol (Marinol)
- Mirtazapine (Remeron)
- Steroids like prednisone or dexamethasone (Decadron)
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Hunger, Medications, Lack Of Appetite
Here are some things to try for lack of appetite:

- Eat small meals or snacks frequently, perhaps every couple of hours.
- Eat snacks that are high in protein or calories, such as nutrient bars, ensure nutrition drinks, milk shakes, cheese, fruits, peanut butter, nuts, crackers, and juices.
- Drink dense fluids such as milk, milk shakes, and juice.
- Prepare food that is colorful and appealing to the senses.
- Try different seasonings
- Cook the food in glass containers.
- Use plastic utensils.
- Alcohol - one glass of wine or beer may help stimulate your appetite
- Try mints, candies, or gum to remove the bad taste in your mouth.
- Eat with others, make it a social event, change the time and setting, or watch tv to take your mind off of eating.
- Rinse your mouth out before you eat to cleanse your tastebuds, try the following - tea, ginger ale, salted water, baking soda in water
Question by: JKJones (Pharmacist (Verified)) in topic(s) Bad Taste, , Metallic Taste, Side Effects, Appetite Changes, Not Hungry, Lack Of Appetite
Angioedema is a type of swelling deep in the skin, many times occuring around your eyes and lips. It is commonly caused by allergic reactions.

Lymphedema is an accumulation of fluids in the lymph system, usually occurring in the arms or legs. It is commonly caused by surgery or radiation therapy.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Angiodema, , Lymphedema, Allergic Reactions, Side Effects, Swelling
Here are some tips to ease the swelling:

- Some exercises to perform several times per day include:
- Hold the swollen arm higher than your heart for specific periods of time (15, 30, 45 minutes). You may do this while you're lying down.
- Open and close your hand 15 to 25 times while your arm is higher than your heart.
- Keep the limb with lymphedema raised higher than the heart when possible.
- Do not swing the limb quickly in circles or let the limb hang down.
- Use your arm normally as much as possible.
- Avoid tight clothes
- Do not carry things using the arm with lymphedema.
- Do not use a blood pressure cuff on the arm with lymphedema.
- Do not apply heat to the limb.
- Massage
- Practice good skin care - lotion to keep skin moist, ointment to treat cuts or breaks in skin, avoid needle sticks,
- Wear compression bandages or garments.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Lymphedema, Tingling Sensations In Arms, Fluid Retention, Arm Swelling
A swollen arm may be a sign of lymphedema. There are many other issues that could cause a swollen arm though. You should consult with your physician.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Lymphedema, Swelling, Arm Swelling
Lymphedema is a lymphatic obstruction (blockage of the lymph nodes). It is swelling due to accumulation of lymphatic fluid. The swelling commonly occurs in an arm or leg.

Lymphedema is common in breast cancer patients who have undergone surgery or radiation therapy.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Lymphedema, Side Effects
If you have a nose bleed that does not stop after 10 to 20 minutes, notify your physician right away or an alternative is to go to the emergency room or an urgent care center.

This could be a serious issue and potential causes are: infection, side effects from medications.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Unexplained Bleeding, Infection, Side Effects, Nose Bleeds
If you have blood in your urine, notify your physician right away. Or an alternative is to go to the emergency room or an urgent care center.

Blood in the urine could signify serious health issues and should be treated as soon as possible. Some cause are: infections, side effects from medications, kidney stones.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Urinary Tract Infection, Unexplained Bleeding, Infection, Blood In Urine, Side Effects, UTI
Neupogen (Filgrastim) and Neulasta (Pegfilgrastim) are medications prescribed to patients with low white blood cell counts.

These medications are natural proteins which help stimulate the bone marrow to produce white blood cells. Neulasta has a "PEG" (polyehtylene glycol) added to the molecule making it last longer in your body than Neupogen.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Filgrastim, Neutropenia, Pegfilgrastim, Neupogen, , White Blood Cell Counts (WBC), Medications, Neulasta
Neutropenia is a low neutrophil count. Neutrophils are a type of white blood cell that protects the body from infections caused by bacteria and fungi. Neutropenia results in a weak immune system which increases the risk of an infection.

Neutropenia is a potential side effect of chemotherapy treatments and radiation therapy. Chemotherapy medications attack healthy cells as well as cancer cells and this includes attacking white blood cells.

At risk patients of neutropenia should be watched very closely for fevers and other signs of infection. Neutropenia may be diagnosed from a blood cell count.

If you have neutropenia, your doctor may need to delay chemo treatment or reduce your chemotherapy dose until your white blood cell count increases and the possibility of infection is diminished.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Filgrastim, Neutropenia, Neupogen, Pegfilgrastim, , White Blood Cell Counts (WBC), Medications, Neulasta
There are three different types of hormonal therapy medicines:

- AIs (Aromatase Inhibitors):
- Arimidex (anastrozole)
- Aromasin (exemestane)
- Femara (letrozole)

- SERMs (Selective Estrogen Receptor Modulators):
- tamoxifen
- Evista (raloxifene)
- Fareston (toremifene)

- ERDs (Estrogen Receptor Down Regulators):
- Faslodex (fulvestrant)
Question by: JKJones (Pharmacist (Verified)) in topic(s) ERDs, Hormonal Medications, , Aromatase Inhibitors, Hormonal Therapy, Medications, SERMs
It is believed that HRT may increase the risk of new and recurring breast cancer. The reason why is that HRT increases the estrogen in the body and estrogen may stimulate the growth breast cancer cells.

If you have severe menopausal symptoms, try to find a doctor who will look closely at your individual case.
First of all, your physician should test to make sure that you are post-menopausal.

Aromatase inhibitors are the most common hormonal treatment for post-menopausal women. The three most prescribed are:
- Arimidex (chemical name: anastrozole)
- Femara (chemical name: letrozole)
- Aromasin (chemical name: exemestane)

Alternative treatments are:
- tamoxifen
- Faslodex (fulvestrant)
- Fareston (toremifene)
- Megace (megestrol)
- Halotestin (fluoxymesterone)

A combination of the above therapies might be considered in some cases.

If the side effects are too severe, you might consider changing treatments.

Sometimes though, the cancer changes and the hormonal treatment is ineffective or might even fuel the cancer. In these cases, the treatments should stop and potentially another hormonal therapy can be tried.
Potential benefits of tamoxifen for hormone receptor positive breast cancer:
- helps to prevent growth of cancer in the breast
- reduces the risk of cancer recurrence in the breast
- reduces the risk of new cancer in the breast

Potential risks of tamoxifen:
- increases the risk of blood clots, strokes, uterine cancer, and cataracts
- less serious side effects are similar to menopause, such as: hot flashes and vaginal discharge

Research thus far has not shown that tamoxifen and other anti-estrogen medications are effective for hormone (estrogen and progesterone) receptor negative breast cancer tumors.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Tamoxifen Risks, Tamoxifen Benefits, Hormonal Therapy, Nolvadex (Tamoxifen)
Tamoxifen may be considered as a potential treatment for hormone receptor positive breast cancers in the following situations:
- to prevent growth of early-stage breast cancer (i.e. DCIS - ductal carcinoma in situ)
- to prevent growth of metastatic breast cancer
- as adjuvant therapy (treatment after the primary treatment to reduce chance of recurrence or continued growth)
- to prevent development of breast cancer in high risk women
- adjunctive and palliative treatment of advanced breast cancer

Research thus far has not shown that tamoxifen and other anti-estrogen medications are effective for hormone (estrogen and progesterone) receptor negative breast cancer tumors.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Hormonal Therapy, Tamoxifen Examples, Tamoxifen Cases, Nolvadex (Tamoxifen)
Deciding to take any medication is a personal decision and the benefits and risks specific to you should be taken into consideration.

Some of the factors that should be considered are:
- specifics of the diagnosis - hormone receptor status, stage of disease, etc.
- family history and hereditary risk of breast cancer
- specifics of the prognosis
- risk of recurrence
- treatment and surgery history
- personal risk tolerance
- potential benefits and risks of tamoxifen

Potential benefits of tamoxifen for hormone receptor positive breast cancer:
- helps to prevent growth of cancer in the breast
- reduces the risk of cancer recurrence in the breast
- reduces the risk of new cancer in the breast

Potential risks of tamoxifen:
- increases the risk of blood clots, strokes, uterine cancer, and cataracts
- less serious side effects are similar to menopause, such as: hot flashes and vaginal discharge

High benefit of tamoxifen example:
Someone who has had a lumpectomy for an invasive cancer and positive lymph nodes is probably a high risk of recurrence and the benefits of tamoxifen likely outweigh the risks. Unless this person has a high risk of blood clots, in which case they should consider other hormonal treatment options.

Low benefit of tamoxifen example:
Someone who has had a bilateral mastectomy for a non-invasive cancer (DCIS) is probably a low risk for recurrence and the risks of tamoxifen would likely outweigh the benefits.
For pre-menopausal women with estrogen positive breast cancer, the hormonal treatment options are:
- tamoxifen is the most common treatment
- medications that temporarily stop the ovaries from producing estrogen are: Zoladex (goserelin acetate), Lupron (leuprolide), or Trelstar (triptorelin)
- surgical removal of ovaries
- radiation treatment to stop ovaries from working

A couple of less common treatments are Megace (megestrol) and Halotestin (fluoxymesterone). These treatments are used in specific cases.
The discomforts of menopause are caused by the ovaries producing less estrogen. If your ovaries are removed, your body no longer produces estrogen, and therefore will experience the same side effects as a woman going through menopause.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Removal Of Ovaries, , Side Effects, Ovaries, Menopause Side Effects
For women, reduced estrogen levels sometimes confuses the part of your brain (hypothalamus) that controls your body temperature, appetite, sleep cycles, and appetite. When this happens, the brain will send messages to the heart, blood vessels, and nervous system to increase blood flow, thus causing hot flashes and increased body temperature.

Hot flashes are common with women going through menopause. During menopause, a woman's ovaries produce less estrogen. This is a natural process for women as they age.

Hot flashes may also be caused medically through medications (ovarian shutdown medications and hormonal medications) or removal of ovaries.

Ovarian shutdown medications include: Zoladex (goserelin acetate), Lupron (leuprolide), and Trelstar (triptorelin)
Hormonal medications include: Arimidex (anastrozole), Aromasin (exemestane), Femara (letrozole), Tamoxifen, Evista (raloxifene), Fareston (toremifene), and Faslodex (fulvestrant).
To reduce the effects of hot flashes, keep cool. Slight increases in your body's core temperature can trigger hot flashes. Dress in layers so that you can remove outer clothing when you feel too warm. Open a window or use a fan or air conditioner to keep air flowing. Lower the room temperature, if you can. If you feel a hot flash coming on, sip a cold or cool drink. Apply a cool damp pad to your forehead.

Watch what you eat and drink. Hot and spicy foods, caffeinated beverages and alcohol can trigger hot flashes. Learn to recognize your own triggers and avoid foods or drinks that bring on hot flashes.

Relax. Some women find relief from mild hot flashes through yoga, meditation, relaxation or other stress-reducing techniques. Breathe deeply. Deep, slow abdominal breathing (paced respiration) may decrease hot flashes.

Don't smoke. Smoking is linked to increased hot flashes.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Lifestyle Changes, Hot Flashes, Side Effects, Treatments, Home Remedies
Here are some suggestions to manage hot flashes better:

- Drink cool liquids.
- Lower the room temperature, turn on the air conditioner, or turn on a fan.
- A cool damp cloth may be placed on your forehead during a hot flash.
- Dress lightly and wear loose fabrics.
- Avoid hot flash triggers such as spicy food, hot food or drink, cigarettes, alcohol, caffeine, and stressful situations.
- Cool showers may help.
- During a hot flash practice slow, deep breathing.
- Try relaxation techniques such as yoga or meditation.

For severe hot flashes your doctor might recommend taking a break from your treatment for a week. Then restart at a lower dose and slowly increase the dose, allowing your body to adjust to the treatment.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Hot Flashes, Side Effects, Hormonal Side Effects, Managing Hot Flashes
Hormonal Therapy is very different from Hormone Replacement Treatments (HRT). They are almost the opposite of each other. Hormonal therapies inhibit the body's production of hormones, while hormone replacement treatments add hormones to the body.

Hormonal therapies (anti-estrogen) are used to treat hormone receptor positive breast cancers by either stopping the body's production of hormones or inhibiting hormones from attaching to cancer cell hormone receptors.

Hormone replacement therapy (HRT) refers to treatments that some women take during or following menopause that add hormones to the body. The purpose of HRT is to relieve some of the effects of menopause such as hot flashes. HRT is not a breast cancer treatment and it may increase your risk of breast cancer.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Hormone Replacement Therapy, , Hot Flashes, HRT, Menopause, Hormone Therapy
The first step in treating women with breast cancer is to surgically remove the cancer from the breast. It is difficult to be certain though that every cancer cell has been removed at the time of surgery because some breast cancer cells could have spread to surrounding tissues or other organs prior to the operation. Therefore, women often receive some type of treatment after surgery (adjuvant therapy) to prevent the growth of any cancer cells that might remain in the body. Studies show that when tamoxifen is used for this purpose in Estrogen Receptor positive cancers, the risk of cancer recurrence is reduced.
For pre-menopausal women with estrogen positive breast cancer, the alternatives for tamoxifen are:
- medications that temporarily stop the ovaries from producing estrogen: Zoladex (goserelin acetate), Lupron (leuprolide), or Trelstar (triptorelin)
- surgical removal of ovaries
- radiation treatment to stop ovaries from working

A couple of less common treatments are Megace (megestrol) and Halotestin (fluoxymesterone). These treatments are used in specific cases.

For post-menopausal women, Aromatase inhibitors are considered a better option in most cases.
Tamoxifen works by interfering with the effects of estrogen in the breast tissue. If a patient is determined to have estrogen positive (ER+) breast cancer, estrogen may be fueling the growth of cancer cells in the breast. Tamoxifen binds to the cancer cells in the breast preventing cancer cells from binding with estrogen, thereby keeping the cancer cells from reproducing.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Mechanism Of Action, , Estrogen, Nolvadex (Tamoxifen)
Certain medical treatments may damage a woman's ovaries, suppress her estrogen and progesterone levels, and stop the ovaries from working. The treatments that may cause medical menopause are chemotherapy, anti-estrogen hormone therapies, and pelvic radiation. These treatments may cause a sudden drop in female hormone levels, resulting in temporary or permanent menopause with all the side effects of menopause. Younger women may only experience temporary menopause.

Breast cancer chemotherapy regimens that may cause medical menopause include cytoxan, methotrexate, and fluorouracil. According to BreastCancer.org, with treatment of these medications, fifty percent of women younger than 35, 80% of women 35–44, and nearly 100% of women over 45 will go into menopause. With adriamycin chemotherapy, the risk of permanent menopause is somewhat less for women under 40, but it is similar to that of cytoxan, methotrexate, and fluoruacil in women over 40.

If you are taking HRT (Hormone Replacement Treatment medications) for menopause symptoms and are diagnosed with breast cancer, you may stop the HRT treatments and this will result in a drop in estrogen levels and menopause.

If your ovaries are surgically removed you will experience menopause right away. This is called surgical menopause.
Hair loss (alopecia) is a common and distressing side effect from chemotherapy.

Hair loss depends on the chemo medication and dosages being administered. The loss of your hair may happen all at once or more slowly and you may lose all your hair or just some of it. Your eyelashes, eyebrows, and pubic hair may also be affected. It may occur in the second or third week after beginning treatments, or even after multiple cycles of treatment.

The important thought to keep in mind is that hair loss is temporary. Hair typically grows back 3-6 months after treatments are completed.

Hair loss cannot be prevented during chemotherapy and there is no treatment for it. Here are some suggestions to help deal with hair loss:
Have a short haircut before starting treatments.
Buy a wig.
Buy caps and learn how to tie scarves in unique ways.

Question by: JKJones (Pharmacist (Verified)) in topic(s) Alopecia, , Hair Loss And Changes
One of the potential side effects from chemotherapy treatments is low blood platelets, which may result in a bleeding disorder (unexplained bruising and bleeding).

You should be watching for the following:
- tiny, red, pinpoint spots on your skin (petechiae)
- bleeding from a cut that doesn't stop after a few minutes
- bleeding from your mouth or nose (nose bleed called epistaxis)
- black or bloody stools
- bleeding from your vagina when you are not having your period (menstruation)
- bleeding during your period that is heavier or lasts longer than normal
- changes in how well you see
- feeling confused or very sleepy
- changes when you go to the bathroom
- blood in your urine (the urine will have a red or pink color to it)
- head or vision changes
- bad headaches
Question by: JKJones (Pharmacist (Verified)) in topic(s) Bleeding, Chemo Side Effects, , Bruising, Hematoma (Blood Build-Up), Petechiae, Red Spots, Side Effects
A flare reaction is a temporary worsening in the symptoms. Hormonal therapies can cause a "flare" reaction shortly after they are started. Although uncomfortable, a tumor flare reaction can be a sign that the hormonal treatment is working and is often followed by a positive response. Patients should be monitored closely the first few weeks after beginning treatment. If needed, side effects can be treated.

The worsening symptoms could be an increase in pain, tumor size, redness around the tumor, or new lesions.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Hormonal Therapy, Side Effects, Pain, Increased Calcium, Flare Reaction
Some of the common symptoms of menopause are: hot flashes, heart pounding and racing (palpitations), night sweats, skin flushing, and difficulty sleeping.

Yes, you will more than likely experience menopause symptoms if you have your ovaries removed. Always remember each person experiences different symptoms to different degrees.

There are other symptoms of menopause which you may experience as well, but these are not as prevalent. You may see a decreased interest in sex, a little forgetfulness, irregular menstrual periods, mood swings, vaginal dryness, and joint aches.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Heart Pounding, , Skin Flushing, Menopausal Symptoms, Night Sweats, Sleeping Problems, Menopause
Leukopenia (also known as leukocytopenia, or leucopenia) is a decrease in the number of white blood cells. White blood cells fight infection. A patient with leukopenia is more susceptible to infection.

Leukopenia is a potential side effect of many chemotherapy and chemo prevention medications.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Leukopenia, Infection, Chemo Side Effect, White Blood Cells, Side Effects
Thrombocytopenia is any disorder in which there are not enough platelets. Platelets are cells in the blood that help blood to clot.

Thrombocytopenia is a potential side effect of many chemotherapy and chemo prevention medications.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Platelets, Chemo Side Effects, , Side Effects, Thrombocytopenia
Common side effects of tamoxifen include hot flashes, nausea, weight gain, headaches, vaginal bleeding, vomiting, bone pain, thrombocytopenia, and leukopenia.

Tamoxifen side effects vary greatly from patient to patient depending on different issues including patient history, existing conditions, other prescribed medications the patient is taking, and stage of disease. Some people experience minimal side effects, while others experience severe side effects.

If the side effects from tamoxifen are severe, you may speak to your physician about alternative options or medications to treat the side effects. Your options will depend on whether you are pre-menopausal or post-menopausal.

Some side effects may indicate a positive therapeutic response, such as bone pain and tumor flare reaction.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Bone Pain, , Hot Flashes, Side Effects, Flare Reaction, Nolvadex (Tamoxifen)
Side effects will vary greatly from patient to patient depending on many issues including medications, treatments, patient history, and other existing conditions (i.e. hypertension, diabetes, heart failure, etc.).

Many times, the side effects that are experienced during the first treatment are good indicators of the side effects that will be experienced during future treatments. Prior to each treatment, medications may be prescribed to minimize the side effects. As treatments continue, side-effect medications may be adjusted to optimize effectiveness. Some side effects may be cumulative such as fatigue.

Speak to your physician and medical team prior to treatments to get a better idea of potential side effects specific for you and keep them informed of any changes to how you feel.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemo Side Effects, , Medications, Side Effects, Chemotherapy
It depends on the type of chemotherapy, your age, and if you have other health problems.
Make sure to communicate with your physician that you want to consider having children in the future.

Make sure you do not get pregnant during chemo, which could cause adverse issues with the fetus.

Another option that women are considering is to freeze their ova.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Having A Baby, Fertility, Infertility, Side Effects, Pregnancy
Discuss your memory loss with your oncologist first. The physician might recommend a neurological workup to rule out other issues.

Make sure you’re doing your best to take care of your whole mind and body.

If you can’t remember things, write them down. Keep lists of important tasks to complete. Keep a calendar to keep track of important dates.

Slow yourself down and be patient. If you can’t come up with the name for the phone, computer, etc., explain or show what it does.

Don't feel obligated to make quick decisions. Take your time in processing information.

Sign up for a cancer survivor support group. Many people get support during treatment but never seek support for the ongoing side effects after chemotherapy. Hearing similar stories and having others to commiserate with is good for your soul.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Memory Loss, Chemo Side Effects, Forgetfulness, Side Effects, Chemo brain
No medications have been approved to treat chemo brain, but you may consult your physician for medications that are used to treat similar issues.

Some medications that might be considered are:

- Methylphenidate (Concerta, Ritalin), a drug approved for attention-deficit/hyperactivity disorder (ADHD)
- Donepezil (Aricept), a drug used in people with Alzheimer's disease
- Modafinil (Provigil), a drug used in people with certain sleep disorders
Question by: JKJones (Pharmacist (Verified)) in topic(s) Memory Loss, Chemo Side Effects, , Forgetfulness, Medications, Side Effects, Chemo brain
Ideas to help:

- Repetitive exercises to train your brain such as brain teasers and crossword puzzles.
- Coping strategies such as reminder notes, developing routines, carrying a notepad, etc.
- Stress-relief techniques such as yoga, naps, breathing exercises, etc.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Memory Loss, Chemo Side Effects, , Forgetfulness, Side Effects, Chemo brain
Chemobrain refers to someone who is experiencing memory loss or feels like their mind is not moving as quickly as usual either during or after chemotherapy treatments.

It is not clear what causes chemo brain and no standard treatment has been developed.

Other issues or side effects of chemotherapy might be contributing to the memory problems and should be investigated. Examples are anemia, depression, sleep problems and early menopause. Controlling these factors may make it easier to cope with chemobrain.

In most cases, cancer-related memory problems are temporary, so treatment focuses on coping with symptoms until they eventually subside.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Memory Loss, Chemo Side Effects, , Forgetfulness, Chemo-brain, Side Effects
Yes. "Chemo brain” or memory loss after chemo is common. Research has found that memory loss from chemo is usually short term. It can affect the ability to think quickly, focus, and multi-task.

As of now, there is no treatment. It is recommended to keep your mind active (i.e. mind games). You may carry a notepad around and utilize reminders. Do not feel obligated to make quick decisions.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Memory Loss, Chemo Side Effects, , Forgetfulness, Chemo-brain, Side Effects
Side effects from chemotherapy can affect the skin, gastrointestinal tract, bone marrow, and general health.

General health side effects include fever, body aches and pains, and fatigue. Various medications can be used to treat these general side effects (e.g., acetominophen, ibuprofen, narcotic pain relievers). Other treatment options include physical therapy, counseling, and support groups.

Skin side effects include skin rashes, dry skin, and temporary hair loss (alopecia).

Gastrointestinal (GI) tract side effects may include nausea and vomiting, loss of appetite (anorexia), mouth sores, and inflammation of the esophagus. Changes in the gastrointestinal tract may result in diarrhea or constipation. In many cases, treatment is available to help prevent or substantially reduce the severity of these side effects.

Bone marrow side effects include the reduced production of red blood cells, white blood cells, and platelets. This might cause a reduction of oxygen in the body, bleeding because of lack of platelets, and infections due to fewer white blood cells.

In rare cases, intravenous chemotherapy drugs can leak from the intravenous line or from the patient's vein into surrounding tissue. This is a potentially serious side effect, which is called extravasation and may result in damage to skin, tissue, muscle, and nerves.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemotherapy Medications, , Medications, Side Effects, Chemotherapy
Speak to your physician, nurse, and pharmacist and be as specific as possible describing your pain. Including location, what it feels like (sharp, dull, or throbbing), how painful on a scale from 0 to 10, how long it lasts, what makes the pain better or worse, time of day, and if your current medications are helping. Let them know if your pain changes. Take your medications on a regular schedule and do not skip doses. It might be best to meet with a pain or palliative care specialist.

Skipping doses might result in increased pain and difficulty in keeping pain under control.

Some of the actions your physician might consider are increasing the dosage and adding or changing medications.

Make sure you talk about your pain with trusted relations and reveal your emotions.

Additional considerations include deep breathing, yoga, and other relaxation techniques.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemo Side Effects, Aching, Side Effect, Side Effects, Pain, Throbbing, Soreness
Scar tissue is dense fibrous connective tissue that forms over and/or around a healed wound or cut. Scar tissue is the body's way of repairing and protecting damaged tissues.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Scar Tissue, Scarring
The first thing to do is to lightly stretch and massage the scar area daily (especially during the first year, when most healing occurs). When massaging, gently cross the incision from side to side. Also while massaging, be alert for lumps around or under the scar tissue, which might indicate reoccurrence.

Ointments may also be used. Some examples are eucerin, bio skin repair, scarprin, dermatix, ultratalsyn, zen-med, kelocote, and woundbegone.

Physical therapy could help if the scar tissue is causing stiffness, pressure, or pain.

Consult your doctor if the scar tissue is very painful.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Ointments, Red Tissue, Scar Contracting, Scarring, Massage
Examples of combination regimens and their acronyms are (Chemotherapy schedules and dosages vary depending on stage of disease.):

- AC (Doxorubicin I.V. and Cyclophosphamide I.V.)
- ACe (Doxorubicin I.V. and oral Cyclophosphamide)
- CAF (Cyclophosphamide oral, Doxorubicin, Fluorouracil OR Cyclophosphamide, I.V., Doxorubicin, Fluorouracil)
- CEF (Cyclophosphamide oral, Epirubicin I.V, Fluorouracil I.V.)
- CMF (Methotrexate I.V., Fluorouracil I.V., Cyclophosphamide Oral)
- CMF I.V. (Cyclophosphamide I.V., Methotrexate IV., Fluorouracil I.V.)
- CNF (Cyclophosphamide I.V., Mitoxantrone I.V., Fluorouracil I.V.)
- FAC (Fluorouracil, Doxorubicin, Cyclophosphamide)
- FEC (Fluoruracil I.V., Cycloposphamide I.V., Epirubicin I.V.)
- M-VAC (Methotrexate I.V., Vinblastine I.V., Doxorubicin I.V., Cisplatin I.V.)
- PV (Paclitaxel IV, Vinorelbine I.V.)
- Sequential Dox-CMF (Doxorubicin followed by CMF)
- TAC (Docetaxel IV, Doxorubicin I.V., Cyclophosphamide I.V.)
- Tamoxifen-Epirubicin
- Trastuzumab-Paclitaxel
- VATH (Vinblastine I.V., Doxorubicin, Thiotepa I.V., Fluoxymesterone oral)

****I.V. is administration intravenously.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemotherapy Regimens, , Chemo Medications, Medications, Treatments, Chemotherapy
Here are some daily activities to better manage anemia:
- Rest
- Eat high protein foods (i.e. meat, peanut butter, eggs)
- Eat foods with iron (i.e. red meat, collard greens, spinach, cooked dried beans, liver)
- Stay hydrated by drinking water, gatorade, etc.
- Make sure you are getting your vitamins from diet or multi-vitamins
Question by: JKJones (Pharmacist (Verified)) in topic(s) Red Blood Cells, Rest, Anemia, Foods High In Iron, Vitamins, Side Effects, Tips
The most common symptoms of anemia are:
- feelings of weakness
- fatigue
- feelings of lightheadedness or dizziness
- faster than usual heart rate
- headaches
- pale skin (nail beds)
- feelings of mental confusion or mood changes including irritability
- ringing in the ears (tinnitus)
- feeling out of breath (especially during exercise)

The severity of the symptoms will vary depending on the degree of anemia. Anemia may be present without any of these symptoms and may be discovered during a visit to your physician with blood tests results.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Anemia, , Side Effects, Red Blood Cell Count, Fatigue
Anemia is determined by the hemoglobin and hematocrit measurements from a complete blood count (CBC).

The hemoglobin result is part of a complete blood count (CBC) and measures the amount of hemoglobin in the blood. The amount of hemoglobin in the blood is a measure of the ability of the blood to transport oxygen to the rest of the body.

The hematocrit is a measurement of the proportion of the red blood cells in the blood.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Red Blood Cells, Hemoglobin, Anemia, Hgb, Hct, Side Effects, Hematocrit, Complete Blood Count (CBC)
Hemoglobin is the protein in red blood cells that carry the oxygen to the rest of the body. A blood test determines the amount of hemoglobin (Hgb) in blood.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Hemoglobin, Blood Test,
Anemia is when there is a decreased number of red blood cells. The purpose of red blood cells is to carry oxygen from the lungs to the rest of the body.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Red Blood Cells, Anemia, Side Effects
Symptoms of blood pressure changes may include:
- Fatigue - tiredness, weakness, difficult to do daily activities
- Dizziness or a feeling of fainting when changing positions such as arising from bed, standing or sitting up
- Nauseated
- Perceiving irregular heartbeats
- Experiencing sweatiness
- Experiencing chills
- Breathlessness and chest pain due to the heart not having enough blood to pump throughout the body
- Skin palor (pale)

Factors contributing to hypotension and low blood pressure include:
- Side effects or adverse effect of chemotherapy treatment
- Situations that decrease the amount of blood in the body and therefore decrease the amount of blood the heart can pump
- Certain medications
- Losing fluids from nausea, vomiting and diarrhea which leads to lower than normal amount of blood in your body
- Dehydration may also occur from hot weather, exercising, sweating, or fever
Make sure to track what causes low blood pressure for you and discuss with your health care provider.

Some tips manage hypotension are:
- Drink lots of water, gatorade, etc. to avoid dehydration.
- Eat a healthy diet of fruits, vegetables, carbohydrates, etc.
- Your doctor may recommend adding a moderate level of salt to your diet to increase blood pressure.
- Move slowly and take short rests between getting up, lying down, sitting, or standing. Don't stand up quickly or get out bed quickly.
- Stay out of the heat. This includes hot baths or showers, which might cause your blood pressure to drop even more.
- Try not to drink alcohol. Alcohol can contribute to low blood pressure and dehydration.
- Know your medications, because many medications may affect your blood pressure.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Low Blood Pressure, Dizziness, Dehydration, Side Effects, Hypotension
Hypotension is a lower than normal blood pressure reading. Some chemotherapy or biological drugs may cause low blood pressure.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Low Blood Pressure, Blood Pressure, Side Effects, Hypotension
Erythema is redness of the skin (similar to a sunburn), caused by an increase in blood in the lower layers of the skin (also called hyperemia).

It is a result of an injury of the skin, infection, inflammation, or a side effect of treatment, including radiation or chemotherapeutic medications.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemotherapy Side Effects, Red Skin, , Erythema, Hyperemia, Side Effects
Presciption mouthwashes available to help prevent and alleviate mouth sores (mucositis ) include Peridex, Periogard, and MuGard.

Peridex and Periogard contain Chlorhexidine gluconate which is an antiseptic that decreases the bacteria in the mouth. These products help to fight gum infection and reduce the inflammation associated with mouth sores.

MuGard is a prescription mouthwash to help prevent and protect against mouth sores (mucositis). It is applied before and during chemotherapy and radiation treatments. MuGard coats the mouth resulting in a numbing sensation.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Mucositis, Oral Sores, Medications, Prescription Medications, Mouthwashes, Mouth Sores
Yeast infections (also referred to as a fungal infection of the skin) typically occur in the armpits, under the breasts, or in the groin. A yeast infection is a superficial growth of fungus on the skin.

Common symptoms of yeast infection include:
- redness and swelling of the skin
- rash and itchiness
- sometimes a faint white substance appears on the skin and oozing may occur
- pimple like pumps
Question by: JKJones (Pharmacist (Verified)) in topic(s) Yeast Infection, , Symptoms, Redness, Itchiness, Diagnosis, Yeast Infection Symptoms
There is a 1-10% chance of experiencing neuromuscular and skeletal arthralgia from Methotrexate. Treatment of joint pain focuses on alleviating the discomfort.

Here are some things to try to help alleviate this side effect:
-bed rest
-gentle massage therapy
-stretching exercises
- warm baths
-over the counter pain medications such as the nonsteroidal anti-inflammatory agents (ibuprofen, naproxen,or acetaminophen)
-if the pain is severe you may consult your physician for short-term stronger prescription pain medications.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Skeletal Arthralgia, , Methotrexate, Joint Pain, Arthralgia, Side Effects
Preventing a yeast infection during breast radiation treatment, chemotherapy, or during the healing process is essential.

Yeast infections occur in warm, moist, and dark locations on the body surface and skin. To prevent yeast infections or alleviate the symptoms, here are a few tips:

- Keep the area around and under your breasts dry and clean using non perfume, non-antibacterial, non harsh soap with warm water.
- After cleansing, blow dry the breast area and armpit area with a hair blow dryer on warm temperature (this will also be healing).
- Dust the area around, between, and under the breast folds with cornstarch powders to keep the area dry and thus absorb extra moisture and prevent rubbing of the skin surfaces. (Examples of powders include baby powder made from corn starch or sifted kitchen corn starch, but do not employ talc).
- During the day and night make every effort to keep from having skin touch skin and try not to itch or scratch. Consider placing soft cotton under and around your breasts to keep the breasts separated and consider wearing soft loose fitting clothes.
- Wear bras that are soft, but also with enough support to uplift your breasts and keep them apart. Avoid bras or clothes made from nylon or rayon as they may trap sweat and moisture providing an environment for yeast infection to overgrow the natural skin flora.
-Be sure you shower after exercising as sweat trapped under your breasts likewise provides an ideal environment for yeast to grow.
-A well balanced diet is important as well as eating yogurt that has not been heat treated and contains lactobacillus.
- Over the counter anti-fungal creams (such as athlete's foot medicine) may help and are available in pharmacies or pharmacy sections of drug stores.
Desquamation is the natural shedding and peeling of the outermost layers of the skin. When there is damage to the skin or this process is interrupted or changed, there may be additional shedding and peeling.

Excess desquamation my result from a skin injury or a side effect of some chemotherapy treatments.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Chemotherapy Side Effects, , Side Effects, Desquamation, Skin Peeling, Skin Shedding
he following medications may be prescribed by your doctor to treat or prevent infections in your mouth and gastrointestinal tract:
- Anti-fungals: nystatin, clotrimizole, fluconozole
- Anti-bacterials: mouthwash antiseptics - ACT Fluoride Rinse (alcohol free mouthwash), Chlorhexidine Gluconate (Peridex, PerioGard)
- Anti-virals: acyclovir (Zovirax) or famciclovir (Famvir)
- For the gastrointestinal tract, Sucralfate (Carafate) comes in a suspension and may be used to protect the lining of your mouth down to the stomach.
- Prescription analgesics for pain
Question by: JKJones (Pharmacist (Verified)) in topic(s) Gastrointestinal Tract Infections, Medications, Mouth Infection, Treatments, Mouthwash
Mouthwashes that may be used contain salt or baking soda.

Two home remedy mouth washes are:
- add a 1/2 to 1 teaspoon of salt or baking soda in 8 ounces of water.
- equal parts of hydrogen peroxide and water (do not use longer than 2 days)

Listerine has an antibacterial product called "Zero Listerine" which contains no alcohol.

Mouthwashes containing alcohol and lemon glycerin swabs should be avoided because the alcohol will cause burning sensations in the sores.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Over The Counter Mouthwashes, , Oral Sores, Oral Mucositis, Mouth Sores, Treatments
First, make sure you inform your physician, because it might indicate an infection. For example, white spots may indicate a yeast/fungus infection.

To alleviate oral mucositis and encourage healing, medications that may be prescribed are:
- Lidocaine Viscous
- Zovirax (alcohol-free)
- Mycostatin

Or your physician may also prescribe different combinations of medications or mouthwashes. For example:
- Equal parts of Lidocaine Viscous, Zovirax (alcohol-free), and Maalox or Mylanta.
- Equal parts of Lidocaine Viscous, Mycostatin, and Mylanta.

It may be advised to swallow these solutions if experiencing discomfort while swallowing

If the pain is severe oral or intravenous pain, pain medication may be prescribed.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Sore Mouth, , Mucositis, Prescription Medications, Oral Mouth Sores
The treatment goal of mucositis is to relieve the discomfort and prevent infection.

First, make sure you inform your physician, because it might indicate an infection. For example, white spots in the mouth might indicate an infection.

Basic therapy and prevention of infection includes good oral hygiene, daily brushing with a soft toothbrush, and rinsing the mouth every couple of hours with a water and salt/baking soda solution. A home remedy mouthwash is to mix 3/4 teaspoon baking soda in a 16-oz container of water (use of mouthwashes containing alcohol may be painful). Regularly lubricating your lips and corners of your mouth with an unflavored lip balm (not petroleum jelly or Vaseline) may help.

Over the counter treatments for pain relief include acetaminophen liquid, Orajel, and Zilactin-B.

Over the counter treatments to encourage healing include Orabase and Ulcerase.

A 1/2 to 1 ounce antacid liquid may be taken every 3-4 hours as needed to decrease burning sensation.

Prior to chemotherapy, you may try to suck on ice chips or popsicles for 30 minutes, which may reduce the severity of mouth sores.
The treatment goal of mucositis is to relieve the discomfort and prevent infection.

First, make sure you inform your physician, because it might indicate an infection. For example, white spots in the mouth might indicate an infection.

Basic therapy and prevention of infection includes good oral hygiene, daily brushing with a soft toothbrush, and rinsing the mouth every couple of hours with a water and salt/baking soda solution. A home remedy mouthwash is to mix 3/4 teaspoon baking soda in a 16-oz container of water (use of mouthwashes containing alcohol may be painful). Regularly lubricating your lips and corners of your mouth with an unflavored lip balm (not petroleum jelly or Vaseline) may help.

Over the counter treatments for pain relief include acetaminophen liquid, Orajel, and Zilactin-B.

Over the counter treatments to encourage healing include Orabase and Ulcerase.

A 1/2 to 1 ounce antacid liquid may be taken every 3-4 hours as needed to decrease burning sensation.

Prior to chemotherapy, you may try to suck on ice chips or popsicles for 30 minutes, which may reduce the severity of mouth sores.

Medications may be prescribed to help with the discomfort, such as Lidocaine Viscous and other analgesics.

It might be difficult to eat, make sure to get the proper nutrition by eating soft foods.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Stomatitis, , Mouth Ulcers, Erythema, Edema, Oral Sores, Mouth Discomfort, Desquamation, Side Effects, Mouth Sores
Many chemotherapy treatments will have a side effect of hyperpigmentation of the hands and feet. Hyperpigmentation is temporary and will eventually resolve once the drug causing the change is stopped.

If there is itching oral antihistamines such as diphenhydramine may help.

Over the counter creams to lighten the skin may include:
- hydroquinone
- kojic acid
- alpha hydroxy acids
- azelaic acid
- ascorbic acid
- tretinoin (Retinol)
- licorice extract
Pain may be a side effect of Paclitaxel. If pain is caused from Paclitaxel, it is usually temporary (2-3 days).

To alleviate the pain, you may take over the counter pain medications such as anti-inflammatory agents (ibuprofen). If the pain is more severe, you physician may prescribe pain medications.
Mucositis from chemotherapy usually lasts a few of days, but could last longer. Mucositis may occur at every chemotherapy treatment.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Mouth Ulcers, Mucositis, Oral Inflammation, Mouth Sores
When you experience oral sores, it may be difficult and uncomfortable to eat. It is important that your diet includes the necessary proteins, calories, and vitamins.

Make sure to eat high protein and high calorie foods. Some soft and/or semi-liquid examples that might be easier to eat are scrambled eggs, puddings, blenderized or pureed foods, or baby foods.

Liquid supplements (i.e Carnation Instant Breakfast, Ensure, Boost, etc.) are also a good option.

Try to avoid:
- Hot, spicy, cold, crunchy, rough, or acidic foods
- Alcoholic beverages and tobacco products.
- Medications containing alcohol
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Mouth Ulcers, Mucositis, Oral Sores, Diet, Mouth Sores, Nutrition
Oral mucositis is inflammation and ulceration in the mouth. Oral mucositis is a common side effect of cancer treatments and radio therapy.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Mouth Ulcers, Oral Sores, Mouth Discomfort, Oral Mucositis, Oral Ulcers, Mouth Sores
Mucositis refers to inflammation (i.e. ulcers, painful sores) of the mucous linings of the digestive track. Mucositis is a side effect of some chemotherapeutic drugs, biologic response modifiers, radiation therapy, and/or surgery. Mucositis also may interfere with eating, talking, taste, chewing or swallowing.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Mucositis, Mucous Linings, Oral Sores, Mouth, Side Effects, Esophagus
Stomatitis refers to inflammation in the mouth.
Esophagitis refers to inflammation of esophagus.
Mucositis refers to inflammation in the mucous lining of the upper gastrointestinal tract from mouth to stomach (mouth, lips, throat) and surrounding soft tissues.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Stomatitis, , Mucositis, Mucous Linings, Oral Sores, Mouth, Esophagitis, Side Effects, Esophagus
How many treatments of chemotherapy will I get?
How long is each treatment?
How long between treatments?
What is the total duration of the treatments?
What types of chemotherapy will I get?
How will these drugs be given? (oral, intravenous, subcutaneous, or intravenous piggyback)
Where do I go for the treatment?
Should someone drive me to and from treatments?
What side effects can I expect right away?
What side effects can I expect later?
How serious are these side effects?
How long will the side effects last?
Will all the side effects go away when treatment is over?
What can I do to manage or ease these side effects?
When should I call my medical team about these side effects?
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Important Questions, Medications, Length Of Treatment, Treatments, Chemotherapy
Here are some options to try:
- Gently blow the nose at regular intervals.
- For an excessive runny nose try an over the counter antihistamine (also good for seasonal or environmental allergies)
- Saline sprays or rinses help thin the mucous. There are over the counter saline sprays or you can make your own saline solution by dissolving salt in warm water.
- Use a humidifier in your home to help moisten the mucous.
- Drink lots of water to stay hydrated.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Increase Flow Of Mucous Secretions, Rhinorrhea, , Runny Nose Treatments, Treatments, Runny Nose
A runny nose occurs when the tissues or blood vessels in your nasal cavity produce excess mucous. This excess mucous is the result of the body trying to remove viruses, irritants, and allergens.

Runny nose can be caused by a cold, influenza, allergies (to dust, pollen, pet dander, etc.), or as a response to tobacco smoke or spicy foods.

A runny nose usually clears up on its own, but you should see a doctor for any of the following scenarios:
- if the runny nose does not improve in 3 to 4 days
- fever
- shortness of breath or trouble swallowing
- colored mucous (green, brown, black, etc.)
- bleeding, bruising, or rashes
Question by: JKJones (Pharmacist (Verified)) in topic(s) Excess Mucous, Viruses, Bleeding, , Influenza, Allergies, Smoke, Cold Symptoms, Allergens, Colored Mucous, Runny Nose
For over the counter, there are different categories of medication to alleviate constipation.
- Fiber supplements are the safest medication and add bulk to the stool (Recommended to drink lots of water when taking these supplements). Fiber supplements include Metamucil and Fibercon.
- Lubricating laxatives help to move the stool through the colon. One lubricating supplement is mineral oil.
- Stool softeners moisten the stool. Examples of stool softeners are Colace and Surfak.
- Bowel stimulants stimulate the bowel muscles resulting in contractions in the intestines. Examples of bowel stimulants include Senokot, Correctol, and Dulcolax.
- Senna Plus is a combination stool softener and bowel stimulant.
- Hydrating agents draw water into the intestines. Examples of hydrating agents are milk of magnesia, Haley's MO, magnesium citrate, and miralax.

Three prescription medications your physician may prescribe are:
- Osmotic agents (Lactulose, Cephulac,and Sorbitol) which work by pulling water into the intestines, and therefore softening the stool.
- Chloride channel activators (lubiprostone - Amitiza) increase fluid content of the stool.
- Prucalopride assists in gastro-intestinal motility.

Medications should be a last resort for dealing with constipation. Your body starts to depend on the laxatives, so over-the-counter medications should be used sparingly.

Contact your physician right away if you have not had a bowel movement in 2 or more days or if longer than your regular bowel movements.
To help manage constipation:
- drink 8 cups of water or other fluids each day
- be active every day
- eat high fiber foods such as fiber cereals, whole-grain breads, dried beans, raw vegetables, fresh fruit, nuts, and prune juice.
- don't rush and give yourself time to have bowel movements.
Constipation is when a person experiences less frequent or difficult bowel movements.

Constipation may be caused by lack of fiber in the diet, changes in routine, lack of activity, less fluid intake, and some chemo and pain medications.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Constipation Medications, Laxatives, Bound-up, Side Effects, Constipation
Potential causes of diarrhea are:
- cancer medications
- bacteria, viruses, parasites
- some foods
- diseases that affect the digestive system.

Consult a physician if you are dehydrated, have abdominal or rectal pain, have a fever, or blood in your stool.
Diarrhea is an increase in the frequency of bowel movements of watery loose stools.

If diarrhea lasts for more than a couple of days, contact your physician.

One of the primary risks of diarrhea is dehydration due to loss of fluids in bowel movements.
Replacing lost fluids is the first thing that should be treated. Drink water, gatorade, etc.

Over the counter medications for diarrhea include:
- loperamide (Imodium)
- bismuth subsalicylate (Pepto Bismol)
- lactinex, acidophilus (probiotics)

It is important to only take over the counter medications for 2 days and if the symptoms get worse or diarrhea lasts longer, consult with your physician.

For burning and itching around the anus, over-the-counter treatments include healing creams, ointments, suppositories, and pads to alleviate the anal discomfort. These treatments may contain ingredients such as witch hazel (Tucks pads) or hydrocortisone that relieve pain and itching.

An oral prescription medication that may be prescribed is Lomotil / Diphenoxylate if the diarrhea is out of control.

If a patient is in the hospital for diarrhea, they will likely receive an IV to replace lost fluids.
Some tips and ways to manage diarrhea include:

- drinking 8 to 12 cups of clear liquid a day (including gatorade)
- eat low fiber foods such as soft fruit (i.e. bananas), vegetables (i.e. cooked carrots), white rice, broth, white toast, yogurt, etc.
- although advised for children, nutrient enriched liquids such as Pedialyte or Ceralyte
- ask your physician about eating foods that are high in sodium and potassium, which include potatoes and bananas

Avoid the following:
- milk and milk products (i.e. ice cream or cheese)
- high-fat or greasy foods (i.e. fried foods)
- foods that have a lot of fiber, (i.e. citrus fruits)
- very sweet foods (i.e. cakes and cookies)
Question by: JKJones (Pharmacist (Verified)) in topic(s) Loose Stools, Bowel Movement, , Diarrhea, Tips, Side Effects
Potential symptoms of diarrhea are:

- stomach cramps and gas pain
- abdominal swelling
- urgent or uncontrollable bowel movements
- loose bowels
- chills and fever
Some over the counter options include:
- Antihistamines may help prevent nausea and vomiting. These include dimenhydrinate and meclizine hydrochloride.
- Pepto-Bismol, Maalox, and Mylanta may calm upset stomachs.
- lo-dose ranitidine and famotidine

Some potential prescription medications you physician might prescribe are:
- ondansetron (Zofran)
- promethazine (Phenergan)
- prochlorperazine (Compazine)
- aprepitant (Emend)
- dolasetron (Anzemet)
- granisetron (Kytril)
- palonosetron (Aloxi)
- lorazepam (Ativan)
- metoclopramide (Reglan)
- dexamethasone (Decadron)
- famotidine (Pepcid)
- ranitidine (Zantac)
Question by: JKJones (Pharmacist (Verified)) in topic(s) Wretching, Dry Heaving, , Vomiting, Medications, Nausea, Side Effects, Upset Stomach, Heaving
Over the counter anti-fungal creams, powders, or sprays (such as athlete's foot medicine or Clotrimazole) work well.

A prescription from your physican might include Fluconazole (Diflucan) or Nystatin powder, cream, or spray.

Consult your physician about applying Domeboro Soaks.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Fluconazole, Yeast Infection, , Diflucan, Treatments, Nystatin, Anti-fungal Creams
Yes. Sun exposure during radiation treatments is not advised. Radiation damages the skin and sun exposure could make the burning worse and more painful.

It's best to keep the treated area completely out of the sun.

After your radiation treatment is done, the skin that has been exposed to radiation may be more sensitive to the sun than it was in the past. You can go out in the sun and have fun, but continue to protect your skin.

Use a sunblock that is rated SPF 30 or higher on the area that was treated. (A strong sunblock is a very good policy for every inch of your body.)
Apply the sunblock 30 minutes before you go out in the sun. Reapply the sunblock every few hours, as well as when you get out of the water.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Skin Damage, , Radiation Treatment, Treatments, Sun Exposure
To help prevent nausea, here are some things to try:
- try eating bland, easy to digest foods and drinks that will not upset your stomach, such as plain crackers, dry toast, gelatin, and broth
- try drinking one or two lukewarm cups of peppermint tea
- try eating 5 to 6 small meals a day
- have foods and drinks that are warm or cool, not hot or cold
- drink carbonated liquid that is warm and has lost its fizz, such as ginger ale
- take small bites of popsicles or fruit ices.
- suck on sugar-free mints, tart candies, or chewing gum.
- when you feel like vomiting, breathe deeply and slowly and get fresh air.
- stay away from foods and drinks with strong smells.
- acupuncture is an alternative to try as well.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Wretching, Chemo Side Effects, Vomiting, Nausea, Upset Stomach, Side Effects, Tips, Heaving
Yes, you should avoid chlorine. Chlorine is very drying and can make your skin reaction worse.

If you do swim in a pool, you might want to spread petroleum jelly (a product like Vaseline) on the treated area to keep chlorinated water away from your skin.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Radiation Treatment, Vaseline, Treatments, Chlorine
According to the FDA, clinical trials demonstrated Avastin did not increase the survival for women with breast cancer. In fact, the overall survival appeared to be shorter in women who took the drug. The reasons for that are not clear, and the possibility remains that some known or unknown side effect of the drug could have contributed to this outcome.
Question by: JKJones (Pharmacist (Verified)) in topic(s) Medications, Bevacizumab (Avastin), FDA (Food and Drug Administration)
At the beginning of treatment, before you have any side effects, moisturize the skin after your daily treatment with an ointment such as A&D, Eucerin, Aquaphor, Biafene, Radiacare, aloe preparation, vitamin E cream, or emu oil. Some people get some relief by blowing air on the area with a hair dryer set to "cool" or "air" (no heat). Be careful wearing a bra if there are raw areas. Perhaps try soft bras.

If your skin becomes dry and flakey during the course of your treatment, moisturize frequently and cleanse skin gently.

For mild pinkness, itching, and burning, apply an aloe vera preparation or non-prescription 1% hydrocortisone cream thinly over the affected area. Your physician may prescribe lidocaine cream which helps the burning feeling.

If areas become red, itchy, sore, and starts to burn, and low-potency cream no longer relieves your symptoms, ask your doctor for a stronger steroid cream available by prescription. Examples include 2.5% hydrocortisone cream and bethamethasone.

If your skin forms a blister, leave the the blister alone. The blister keeps the area clean while the new skin grows back underneath. Try to keep the area relatively dry washing with warm water. Then apply a non–adherent dressing, such as Xeroform dressings (laden with soothing petroleum jelly) or "second skin" dressings made by several companies. For pain, take an over-the-counter pain reliever (acetominophin), or ask your doctor for a prescription if you need it.

For more severe burn reactions, a typical treatment includes pain pills and silvadene prescribed by the physician. Apply silvadene to the burned skin with pads to cover the area. The pads my be wrapped with gauze.
Question by: JKJones (Pharmacist (Verified)) in topic(s) , Skin Blisters, Radiation Burn, Topical Cream, Silvadene Cream, Treatments, Hydrocortisone Cream
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