There are many ways to perform risk assessment, and the most important is by taking a personal and family history. A prior breast biopsy, especially if it demonstrated "atypical hyperplasia", increases a woman's risk for the future development of breast cancer. Also the number of relatives who have had breast cancer, and their age at diagnosis, is also important. A history of other cancers in the family, especially ovarian cancer, may lead to a recommendation for BRCA gene testing.
There are various risk assessment models available - the most commonly used one is the Gail Model:
http://www.cancer.gov/bcrisktool/ and it uses known risk factors such as age, age at first menstrual period and first term pregnancy, whether or not prior biopsies have been performed (and if so, was atypia present?), and family history. A disadvantage of the Gail model is that it only takes into account first-degree relatives (mother, sister, daughter) and it may underestimate the risk of disease in some women.
A form of genetic testing, known as the OnvoVue test, is a saliva test which assesses various genes involved in breast cancer development; results are reported as standard risk, moderately elevated, and significantly elevated - this test can help us determine if an otherwise asymptomatic woman might be at higher risk for the future development of breast cancer. Additional information on the OncoVue test can be found here -
http://www.cancerriskassessment.com/what-is-oncovue-2.
Another form of risk assessment testing uses milk duct fluid (nipple aspirate fluid) to determine if there are abnormal cells present; the presence of abnormal cells or atypia would mean that a woman is at increased risk for the development of breast cancer and additional testing may be recommended.
Realize that no risk assessment test is a crystal ball - we do not at this point have the ability to predict with certainty if someone will or will not develop breast cancer. However they can help to identify women that might be at higher than average risk for which additional testing might be indicated. Additional information on risk assessment can be found here -
http://www.cfbci.com/halo.html.
There are many ways to perform risk assessment, and the most important is by taking a personal and family history. A prior breast biopsy, especially if it demonstrated "atypical hyperplasia", increases a woman's risk for the future development of breast cancer. Also the number of relatives who have had breast cancer, and their age at diagnosis, is also important. A history of other cancers in the family, especially ovarian cancer, may lead to a recommendation for BRCA gene testing.
There are various risk assessment models available - the most commonly used one is the Gail Model:
http://www.cancer.gov/bcrisktool/ and it uses known risk factors such as age, age at first menstrual period and first term pregnancy, whether or not prior biopsies have been performed (and if so, was atypia present?), and family history. A disadvantage of the Gail model is that it only takes into account first-degree relatives (mother, sister, daughter) and it may underestimate the risk of disease in some women.
A form of genetic testing, known as the OnvoVue test, is a saliva test which assesses various genes involved in breast cancer development; results are reported as standard risk, moderately elevated, and significantly elevated - this test can help us determine if an otherwise asymptomatic woman might be at higher risk for the future development of breast cancer. Additional information on the OncoVue test can be found here -
http://www.cancerriskassessment.com/what-is-oncovue-2.
Another form of risk assessment testing uses milk duct fluid (nipple aspirate fluid) to determine if there are abnormal cells present; the presence of abnormal cells or atypia would mean that a woman is at increased risk for the development of breast cancer and additional testing may be recommended.
Realize that no risk assessment test is a crystal ball - we do not at this point have the ability to predict with certainty if someone will or will not develop breast cancer. However they can help to identify women that might be at higher than average risk for which additional testing might be indicated. Additional information on risk assessment can be found here -
http://www.cfbci.com/halo.html.